Trial reportPloS one2014
Alterations in ileal mucosa bacteria related to diet complexity and growth performance in young pigs.
Trial report in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 33 citations in OpenAlex.
- Liquid feeding of miscellaneous grain and meal diets with enzymes improved growth performance and intestinal health of growing pigs.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2026Article
- A manually curated pig gut microbiome dataset for precision feeding.Scientific data · 2026Article
- Application and utilization of fermentation as a processing tool to mitigate protein putrefaction in plant-based diets.Frontiers in microbiology · 2025Review
- Difference of Microbial Community in the Stream Adjacent to the Mixed Antibiotic Effluent Source.Toxics · 2024Article
- Significance of Mucosa-Associated Microbiota and Its Impacts on Intestinal Health of Pigs Challenged with F18Pathogens (Basel, Switzerland) · 2022Article
- Intestinal microbiota and its interaction to intestinal health in nursery pigs.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2022Review
- Pathogenic Escherichia coli-Specific Bacteriophages and Polyvalent Bacteriophages in Piglet Guts with Increasing Coliphage Numbers after Weaning.Applied and environmental microbiology · 2021Article
- Modulation of jejunal mucosa-associated microbiota in relation to intestinal health and nutrient digestibility in pigs by supplementation of β-glucanase to corn-soybean meal-based diets with xylanase.Journal of animal science · 2021Article
- Replacing dietary antibiotics with 0.20% l-glutamine in swine nursery diets: impact on intestinal physiology and the microbiome following weaning and transport.Journal of animal science · 2021Article
- Intestinal Health of Pigs Upon Weaning: Challenges and Nutritional Intervention.Frontiers in veterinary science · 2021Review
- Influence of the Fermented Feed and Vaccination and Their Interaction on Parameters of Large White/Norwegian Landrace Piglets.Animals : an open access journal from MDPI · 2020Article
- Pyrodextrin enhances intestinal function through changing the intestinal microbiota composition and metabolism in early weaned piglets.Applied microbiology and biotechnology · 2020Article
- DietaryJournal of animal science and biotechnology · 2020Article
- Chlortetracycline Enhances Tonsil Colonization and Fecal Shedding of Multidrug-ResistantApplied and environmental microbiology · 2019Article
- Article
- Effects of dietary supplementation of formaldehyde and crystalline amino acids on gut microbial composition of nursery pigs.Scientific reports · 2018Article
- The impact of epidermal growth factor supernatant on pig performance and ileal microbiota.Translational animal science · 2018Article
- How Can We Define "Optimal Microbiota?": A Comparative Review of Structure and Functions of Microbiota of Animals, Fish, and Plants in Agriculture.Frontiers in nutrition · 2018Review
- Addition of arabinoxylan and mixed linkage glucans in porcine diets affects the large intestinal bacterial populations.European journal of nutrition · 2017Article
- Porcine Epidemic Diarrhea Virus Infection Induced the Unbalance of Gut Microbiota in Piglets.Current microbiology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEvaluation of the prolonged impact of weaning diet on ileal mucosa bacteria and during periods of reduced and improved growth was conducted using 454 pyrosequencing. METHODOLOGY/PRINCIPAL
findingsWeaned pigs were fed HIGH or LOW complexity diets, with or without antibiotics, for 6 weeks, followed by a common grower diet. Pigs were killed at 2 (n = 4 or 5) and 8 (n = 6) weeks post-weaning (periods of reduced and improved growth, respectively). Mucosal bacteria were removed; DNA was extracted and amplified using the V1-V3 region of the 16S rRNA gene. Mucosal bacteria clustered more closely by week post-weaning than diet but 44% of bacterial species did not change from week 2 to 8. There was no effect of diet complexity or antibiotic inclusion on indices of bacterial diversity. Firmicutes made up 91 and 96% of total reads at week 2 and 8, respectively. The proportion of Clostridium paraputrificum increased (P = 0.003) from week 2 to 8 in pigs fed LOW but didn't change in pigs fed HIGH; whereas Clostridium leptum decreased (P = 0.02) from week 2 to 8 in pigs fed LOW but didn't change in pigs fed HIGH. The proportion of Sarcina genus was 3-fold higher in pigs fed A+ compared to A- at week 2 and 5-fold higher at week 8 despite the lack of in-feed antibiotics at that time. CONCLUSIONS/SIGNIFICANCE: Shifts in mucosal bacteria populations may be related to dietary induced changes in growth performance during reduced and improved growth but further studies are required to confirm causative relationship. Weaning diet results in species specific prolonged alterations in mucosal bacteria, particularly where high levels of in-feed antibiotics are used. A considerable portion of ileal mucosal bacteria colonize early and remain stable over time despite changes in diet.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.