ArticleJournal of innate immunity2015
Anopheles gambiae blood feeding initiates an anticipatory defense response to Plasmodium berghei.
Article in Journal of innate immunity, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
36 citing papers in PubMed, 58 citations in OpenAlex.
- Immune-reproductive cross talk in mosquitoes: molecular pathways and energy homeostasis.Parasites & vectors · 2026Review
- Blood feeding, microbiota, and layered mosquito immunity: from pathway phenotypes to vector competence.Frontiers in immunology · 2026Review
- Energetic shifts reflect survival likelihood in Anopheles gambiae.Communications biology · 2025Article
- Article
- Comparative immunological roles of TEP1 inFrontiers in immunology · 2025Review
- Warmer temperature accelerates reproductive senescence in mosquitoes.Frontiers in physiology · 2025Article
- Genome resequencing and genome-wide polymorphisms in mosquito vectors Aedes aegypti and Aedes albopictus from south India.Scientific reports · 2024Article
- Mosquito ageing modulates the development, virulence and transmission potential of pathogens.Proceedings. Biological sciences · 2024Article
- Article
- Steroid hormone regulation of innate immunity in Drosophila melanogaster.PLoS genetics · 2023Review
- A zone-of-inhibition assay to screen for humoral antimicrobial activity in mosquito hemolymph.Frontiers in cellular and infection microbiology · 2023Article
- The ecdysone receptor regulates several key physiological factors in Anopheles funestus.Malaria journal · 2022Article
- Insulin-like peptide 3 stimulates hemocytes to proliferate in anautogenous and facultatively autogenous mosquitoes.The Journal of experimental biology · 2022Article
- Co-option of immune effectors by the hormonal signalling system triggering metamorphosis in Drosophila melanogaster.PLoS genetics · 2021Article
- Impacts of Infectious Dose, Feeding Behavior, and Age ofPathogens (Basel, Switzerland) · 2021Article
- Frequency matters: How successive feeding episodes by blood-feeding insect vectors influences disease transmission.PLoS pathogens · 2021Review
- The Phlebotomus papatasi systemic transcriptional response to trypanosomatid-contaminated blood does not differ from the non-infected blood meal.Parasites & vectors · 2021Article
- Article
- The 20-hydroxyecdysone agonist, halofenozide, promotes anti-Plasmodium immunity in Anopheles gambiae via the ecdysone receptor.Scientific reports · 2020Article
- Variation in the microbiota across different developmental stages of Aedes albopictus is affected by ampicillin exposure.MicrobiologyOpen · 2020Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Mosquitoes have potent innate defense mechanisms that protect them from infection by diverse pathogens. Much remains unknown about how different pathogens are sensed and specific responses triggered. Leucine-Rich repeat IMmune proteins (LRIMs) are a mosquito-specific family of putative innate receptors. Although some LRIMs have been implicated in mosquito immune responses, the function of most family members is largely unknown. We screened Anopheles gambiae LRIMs by RNAi for effects on mosquito infection by rodent malaria and found that LRIM9 is a Plasmodium berghei antagonist with phenotypes distinct from family members LRIM1 and APL1C, which are key components of the mosquito complement-like pathway. LRIM9 transcript and protein levels are significantly increased after blood feeding but are unaffected by Plasmodium or midgut microbiota. Interestingly, LRIM9 in the hemolymph is strongly upregulated by direct injection of the ecdysteroid, 20-hydroxyecdysone. Our data suggest that LRIM9 may define a novel anti-Plasmodium immune defense mechanism triggered by blood feeding and that hormonal changes may alert the mosquito to bolster its defenses in anticipation of exposure to blood-borne pathogens.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.