ReviewThe American journal of the medical sciences2014
Management of severe hyponatremia: infusion of hypertonic saline and desmopressin or infusion of vasopressin inhibitors?
Review in The American journal of the medical sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 28 citations in OpenAlex.
- Severe Cerebral Salt Wasting Complicating Arginine Vasopressin Deficiency After Traumatic Brain Injury.JCEM case reports · 2026Article
- Review
- Urine sodium levels post-saline infusion in differentiating non-edematous hyponatremia.Scientific reports · 2025Article
- The Different Paths That Lead to Hypotonic Hyponatremia, and a Safe Approach to Treatment.Journal of clinical medicine · 2024Review
- [Features of water-electrolyte balance in persons of the older age group].Problemy endokrinologii · 2024Review
- Six Decades of History of Hypertension Research at the University of Toledo: Highlighting Pioneering Contributions in Biochemistry, Genetics, and Host-Microbiota Interactions.Current hypertension reports · 2022Review
- Acute and Chronic Hyponatremia.Frontiers in medicine · 2021Review
- Edelman Revisited: Concepts, Achievements, and Challenges.Frontiers in medicine · 2021Review
- [Hyponatremia-workflow for intensive care physicians].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2020Review
- Impact of serum albumin levels on the body fluid response to tolvaptan in chronic kidney disease patients.International urology and nephrology · 2019Article
- Fluid balance concepts in medicine: Principles and practice.World journal of nephrology · 2018Review
- Efficacy of oral tolvaptan versus 3% hypertonic saline for correction of hyponatraemia in post-operative patients.Indian journal of anaesthesia · 2017Article
- Clinical aspects of changes in water and sodium homeostasis in the elderly.Reviews in endocrine & metabolic disorders · 2017Review
- Hyponatremia: pathophysiology, classification, manifestations and management.International urology and nephrology · 2014Review
- Efficacy of vaptans for correction of postoperative hyponatremia: A comparison between single intravenous bolus conivaptan vs oral tolvaptan.Journal of anaesthesiology, clinical pharmacologyArticle
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
Rapid correction of severe hyponatremia carries the risk of osmotic demyelination. Two recently introduced methods of correction of hyponatremia have diametrically opposite effects on aquaresis. Inhibitors of vasopressin V2 receptor (vaptans) lead to the production of dilute urine, whereas infusion of desmopressin causes urinary concentration. Identification of the category of hyponatremia that will benefit from one or the other treatment is critical. In general, vaptans are effective in hyponatremias presenting with concentrated urine and, with the exception of hypovolemic hyponatremia, can be used as their primary treatment. Desmopressin is effective in hyponatremias presenting with dilute urine or developing urinary dilution after saline infusion. In this setting, desmopressin infusion helps prevent overcorrection of the hyponatremia. Monitoring of the changes in serum sodium concentration as a guide to treatment changes is imperative regardless of the initial treatment of severe hyponatremia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.