ArticlePloS one2014
Comprehensive analysis of preeclampsia-associated DNA methylation in the placenta.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 5 of them syntheses that pooled it.
What it found
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Who cites it
37 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Epigenetic landscape of placental tissue in preeclampsia: a systematic review of DNA methylation profiles.BMC pregnancy and childbirth · 2025Pooled it
- Systematic review supports the role of DNA methylation in the pathophysiology of preeclampsia: a call for analytical and methodological standardization.Biology of sex differences · 2020Pooled it
- Fetal sex and maternal pregnancy outcomes: a systematic review and meta-analysis.Biology of sex differences · 2020Pooled it
- A review of omics approaches to study preeclampsia.Placenta · 2020Pooled it
- Gestational tissue transcriptomics in term and preterm human pregnancies: a systematic review and meta-analysis.BMC medical genomics · 2015Pooled it
- Sex-linked placental DNA methylation associated with early-onset preeclampsia.Research square · 2026Article
- Characterizing placental dysfunction with DNA methylation profiling and placental histopathology.Placenta · 2026Article
- A placental DNA methylation score associated with early-onset preeclampsia and maternal vascular malperfusion pathology.Frontiers in epigenetics and epigenomics · 2026Article
- MethAgingDB: a comprehensive DNA methylation database for aging biology.Scientific data · 2025Article
- Article
- Placental DNA methylation in caesarean sections - a pilot study.Archives of medical science : AMS · 2025Article
- Advancing diagnosis and early risk assessment of preeclampsia through noninvasive cell-free DNA methylation profiling.Clinical epigenetics · 2024Article
- DNA methylation landscape in pregnancy-induced hypertension: progress and challenges.Reproductive biology and endocrinology : RB&E · 2024Review
- Article
- Altered Epigenetic Profiles in the Placenta of Preeclamptic and Intrauterine Growth Restriction Patients.Cells · 2023Article
- eoPred: predicting the placental phenotype of early-onset preeclampsia using public DNA methylation data.Frontiers in genetics · 2023Article
- Selective hypermethylation is evident in small intestine samples from infants with necrotizing enterocolitis.Clinical epigenetics · 2022Article
- eClock: An ensemble-based method to accurately predict ages with a biased distribution from DNA methylation data.PloS one · 2022Article
- WNT3 hypomethylation counteracts low activity of the Wnt signaling pathway in the placenta of preeclampsia.Cellular and molecular life sciences : CMLS · 2021Article
- STAT3-mediated effects of methyltransferase inhibitor 5-aza-2'-deoxycytidine on preeclampsia.American journal of translational research · 2021Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundA small number of recent reports have suggested that altered placental DNA methylation may be associated with early onset preeclampsia. It is important that further studies be undertaken to confirm and develop these findings. We therefore undertook a systematic analysis of DNA methylation patterns in placental tissue from 24 women with preeclampsia and 24 with uncomplicated pregnancy outcome.
methodsWe analyzed the DNA methylation status of approximately 27,000 CpG sites in placental tissues in a massively parallel fashion using an oligonucleotide microarray. Follow up analysis of DNA methylation at specific CpG loci was performed using the Epityper MassArray approach and high-throughput bisulfite sequencing.
resultsPreeclampsia-specific DNA methylation changes were identified in placental tissue samples irrespective of gestational age of delivery. In addition, we identified a group of CpG sites within specific gene sequences that were only altered in early onset-preeclampsia (EOPET) although these DNA methylation changes did not correlate with altered mRNA transcription. We found evidence that fetal gender influences DNA methylation at autosomal loci but could find no clear association between DNA methylation and gestational age.
conclusionPreeclampsia is associated with altered placental DNA methylation. Fetal gender should be carefully considered during the design of future studies in which placental DNA is analyzed at the level of DNA methylation. Further large-scale analyses of preeclampsia-associated DNA methylation are necessary.
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