ArticleBrain, behavior and evolution2014
Evo-devo and the primate isocortex: the central organizing role of intrinsic gradients of neurogenesis.
Article in Brain, behavior and evolution, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 64 citations in OpenAlex.
- Cortical microarchitecture supports preadolescent functional brain network connectivity.bioRxiv : the preprint server for biology · 2026Article
- Article
- Hierarchical Flows of Human Cortical Activity.bioRxiv : the preprint server for biology · 2026Article
- Targeted gene transfer into developmentally defined cell populations of the primate brain.Cell reports · 2026Article
- Investigating hierarchical critical periods in human neurodevelopment.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Spontaneous Fluctuations in Alpha Peak Frequency along the Posterior-to-Anterior Cortical Plane.eNeuro · 2026Article
- Distinct brain age gradients across the adult lifespan reflect diverse neurobiological hierarchies.Communications biology · 2025Article
- Article
- The regional variation of laminar thickness in the human isocortex is related to cortical hierarchy and interregional connectivity.PLoS biology · 2023Article
- Multimodal mapping of regional brain vulnerability to focal cortical dysplasia.Brain : a journal of neurology · 2023Article
- From fossils to mind.Communications biology · 2023Review
- Cortical activity emerges in region-specific patterns during early brain development.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Cortical activity emerges in region-specific patterns during early brain development.bioRxiv : the preprint server for biology · 2023Article
- Intrinsic activity development unfolds along a sensorimotor-association cortical axis in youth.Nature neuroscience · 2023Article
- Neuroanatomical abnormalities in a nonhuman primate model of congenital Zika virus infection.eLife · 2022Article
- Neurodevelopment of the association cortices: Patterns, mechanisms, and implications for psychopathology.Neuron · 2021Review
- Length of the Neurogenic Period-A Key Determinant for the Generation of Upper-Layer Neurons During Neocortex Development and Evolution.Frontiers in cell and developmental biology · 2021Review
- A multi-scale cortical wiring space links cellular architecture and functional dynamics in the human brain.PLoS biology · 2020Article
- Systematic modelling of the development of laminar projection origins in the cerebral cortex: Interactions of spatio-temporal patterns of neurogenesis and cellular heterogeneity.PLoS computational biology · 2020Article
- Shaping brain structure: Genetic and phylogenetic axes of macroscale organization of cortical thickness.Science advances · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Spatial gradients in the initiation and termination of basic processes, such as cytogenesis, cell-type specification and dendritic maturation, are ubiquitous in developing nervous systems. Such gradients can produce a niche adaptation in a particular species. For example, the high density of photoreceptors and neurons in the 'area centralis' of some vertebrate retinas result from the early maturation of its center relative to its periphery. Across species, regularities in allometric scaling of brain regions can derive from conserved spatial gradients: longer neurogenesis in the alar versus the basal plate of the neural tube is associated with relatively greater expansion of alar plate derivatives in larger brains. We describe gradients of neurogenesis within the isocortex and their effects on adult cytoarchitecture within and across species. Longer duration of neurogenesis in the caudal isocortex is associated with increased neuron number and density per column relative to the rostral isocortex. Later-maturing features of single neurons, such as soma size and dendritic spine numbers reflect this gradient. Considering rodents and primates, the longer the duration of isocortical neurogenesis in each species, the greater the rostral-to-caudal difference in neuron number and density per column. Extended developmental duration produces substantial, predictable changes in the architecture of the isocortex in larger brains, and presumably a progressively changed functional organization, the properties of which we do not yet fully understand. Many features of isocortical architecture previously viewed as species- or niche-specific adaptations can now be integrated as the natural outcomes of spatiotemporal gradients that are deployed in larger brains.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.