ArticlePloS one2014
Validation of a low dose simulation technique for computed tomography images.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Simulated low-dose multi-detector computed tomography: spatial effects on surrogate parameters of bone strength at the proximal femur.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025Article
- Dose robustness of deep learning models for anatomic segmentation of computed tomography images.Journal of medical imaging (Bellingham, Wash.) · 2024Article
- Potential for Dose Reduction in CT-Derived Left Ventricular Ejection Fraction: A Simulation Study.Tomography (Ann Arbor, Mich.) · 2023Article
- Low-dose MDCT: evaluation of the impact of systematic tube current reduction and sparse sampling on quantitative paraspinal muscle assessment.Quantitative imaging in medicine and surgery · 2021Article
- Systematic Evaluation of Low-dose MDCT for Planning Purposes of Lumbosacral Periradicular Infiltrations.Clinical neuroradiology · 2020Article
- Finite Element Analysis-Based Vertebral Bone Strength Prediction Using MDCT Data: How Low Can We Go?Frontiers in endocrinology · 2020Article
- Sparse sampling computed tomography (SpSCT) for detection of pulmonary embolism: a feasibility study.European radiology · 2019Article
- Multi-detector CT imaging: impact of virtual tube current reduction and sparse sampling on detection of vertebral fractures.European radiology · 2019Article
- Effects of virtual tube current reduction and sparse sampling on MDCT-based femoral BMD measurements.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2018Article
- Dose reduction in abdominal CT: The road to submillisievert imaging.European radiology · 2018Article
- Can We Perform CT of the Appendix with Less Than 1 mSv? A De-escalating Dose-simulation Study.European radiology · 2018Article
- Low-Dose Computed Tomography for the Optimization of Radiation Dose Exposure in Patients with Crohn's Disease.Gastroenterology research and practice · 2018Review
- Is multidetector CT-based bone mineral density and quantitative bone microstructure assessment at the spine still feasible using ultra-low tube current and sparse sampling?European radiology · 2017Article
- Effect of Low-Dose MDCT and Iterative Reconstruction on Trabecular Bone Microstructure Assessment.PloS one · 2016Article
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeEvaluation of a new software tool for generation of simulated low-dose computed tomography (CT) images from an original higher dose scan. MATERIALS AND
methodsOriginal CT scan data (100 mAs, 80 mAs, 60 mAs, 40 mAs, 20 mAs, 10 mAs; 100 kV) of a swine were acquired (approved by the regional governmental commission for animal protection). Simulations of CT acquisition with a lower dose (simulated 10-80 mAs) were calculated using a low-dose simulation algorithm. The simulations were compared to the originals of the same dose level with regard to density values and image noise. Four radiologists assessed the realistic visual appearance of the simulated images.
resultsImage characteristics of simulated low dose scans were similar to the originals. Mean overall discrepancy of image noise and CT values was -1.2% (range -9% to 3.2%) and -0.2% (range -8.2% to 3.2%), respectively, p>0.05. Confidence intervals of discrepancies ranged between 0.9-10.2 HU (noise) and 1.9-13.4 HU (CT values), without significant differences (p>0.05). Subjective observer evaluation of image appearance showed no visually detectable difference.
conclusionSimulated low dose images showed excellent agreement with the originals concerning image noise, CT density values, and subjective assessment of the visual appearance of the simulated images. An authentic low-dose simulation opens up opportunity with regard to staff education, protocol optimization and introduction of new techniques.
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