ReviewCurrent biology : CB2014
Focusing brain therapeutic interventions in space and time for Parkinson's disease.
Review in Current biology : CB, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- Exercise-Induced Functional Changes in People with Parkinson's Disease following External Cueing and Task-Based Intervention.Rehabilitation research and practice · 2024Article
- Birhythmic Analog Circuit Maze: A Nonlinear Neurostimulation Testbed.Entropy (Basel, Switzerland) · 2020Article
- Deep brain stimulation modulates pallidal and subthalamic neural oscillations in Tourette's syndrome.Brain and behavior · 2019Article
- Myopic control of neural dynamics.PLoS computational biology · 2019Article
- Spatio-temporal dynamics of cortical drive to human subthalamic nucleus neurons in Parkinson's disease.Neurobiology of disease · 2018Article
- Optogenetic stimulation of glutamatergic neuronal activity in the striatum enhances neurogenesis in the subventricular zone of normal and stroke mice.Neurobiology of disease · 2017Article
- New Insights into the Crosstalk between NMDARs and Iron: Implications for Understanding Pathology of Neurological Diseases.Frontiers in molecular neuroscience · 2017Review
- Mechanisms regulating spill-over of synaptic glutamate to extrasynaptic NMDA receptors in mouse substantia nigra dopaminergic neurons.The European journal of neuroscience · 2015Article
- Agency and intervention.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Article
- Differential degradation of motor deficits during gradual dopamine depletion with 6-hydroxydopamine in mice.Neuroscience · 2015Article
- Neuroscience: spotlight on deep-brain stimulation.Nature · 2015Article
- Phase-dependent modulation as a novel approach for therapeutic brain stimulation.Frontiers in computational neuroscience · 2015Article
- Effects of subthalamic nucleus deep brain stimulation on objective sleep outcomes in Parkinson's disease.Movement disorders clinical practiceArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The last decade has seen major progress at all levels of neuroscience, from genes and molecules up to integrated systems-level models of brain function. In particular, there have been advances in the understanding of cell-type-specific contributions to function, together with a clearer account of how these contributions are coordinated from moment to moment to organise behavior. A major current endeavor is to leverage this knowledge to develop new therapeutic approaches. In Parkinson's disease, there are a number of promising emerging treatments. Here, we will highlight three ambitious novel therapeutic approaches for this condition, each robustly driven by primary neuroscience. Pharmacogenetics genetically re-engineers neurons to produce neurotrophins that are neuroprotective to vulnerable dopaminergic cells or to directly replace dopamine through enzyme transduction. Deep brain stimulation (DBS) is undergoing a transformation, with adaptive DBS controlled by neural signals resulting in better motor outcomes and significant reductions in overall stimulation that could reduce side effects. Finally, optogenetics presents the opportunity to achieve cell-type-specific control with a high temporal specification on a large enough scale to effectively repair network-level dysfunction.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.