ArticleIranian journal of reproductive medicine2012
The enhancing effects of alcoholic extract of Nigella sativa seed on fertility potential, plasma gonadotropins and testosterone in male rats.
Article in Iranian journal of reproductive medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The trial behind it
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Who cites it
13 citing papers in PubMed.
- Effects ofInternational journal of molecular sciences · 2026Article
- Multi-Target Mechanisms of Moroccan Aphrodisiac Plants: An Integrative Computational and Phytochemical Investigation.Food science & nutrition · 2026Article
- Ameliorative Role of EthanolicVeterinary medicine international · 2026Article
- Evaluation of Selected Folk Herbs on the Fertility of Sprague Dawley Male Rats: Biochemical, Histological, and Molecular Investigations.Life (Basel, Switzerland) · 2024Article
- Article
- Promoting action of vitamin E and black seed oil on reproductive hormones and organ histoarchitecture of Swiss albino mice.Veterinary medicine and science · 2022Article
- Improvement in the epigenetic modification and development competence in PCOS mice oocytes by hydro-alcoholic extract ofInternational journal of reproductive biomedicine · 2020Article
- Effect of Herbal Medicine on Fertility Potential in Experimental Animals - an Update Review.Materia socio-medica · 2020Review
- Oxidative stress and male infertility: current knowledge of pathophysiology and role of antioxidant therapy in disease management.Cellular and molecular life sciences : CMLS · 2020Review
- Review
- Thymoquinone ameliorates some endocrine parameters and histological alteration in a rat model of polycystic ovary syndrome.International journal of reproductive biomedicine · 2018Article
- Protective effect of Nigella sativa seeds against spermatocyte chromosomal aberrations and genotoxicity induced by carbon tetrachloride in mice.Environmental science and pollution research international · 2017Article
- Male Infertility: The Effect of Natural Antioxidants and Phytocompounds on Seminal Oxidative Stress.Diseases (Basel, Switzerland) · 2017Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe task force on plants for fertility regulation in men continued with its program to identify novel prototypes in plants alleged to have fertility regulating properties. Nigella Sativa seeds are frequently used in folk medicine in the Middle East and some Asian countries for the promotion of good health and treatment of many ailments.
objectiveTo evaluated the role of alcoholic extract of Nigella sativa on fertility potential, Pituitary-testicular axis hormones and Testosterone in male rats. MATERIALS AND
methods24 male rats were randomly divided into 3 groups; control, group A and group B, each group comprising of 8 rats. Animals in control group received 1 ml of normal saline and treatment groups (A and B) received (gavage) graded doses of 200 and 400 mg/kg body weight of alcoholic extract of Nigella sativa seeds on a daily basis for 60 days. At the end of treatment period, fertility parameters such as body and reproductive organs weight, sperm motility, viability and count, epididymal sperm reserve (ESR), daily sperm production (DSP), blood testosterone concentration, Gonadotropins levels and fertility index were measured.
resultsThere was a significant difference in testes and epididymidis weight, sperm count, ESR, DSP, blood testosterone concentration, LH and fertility index in both the lower dose group and the higher group as compared to the control group.
conclusionThe results of this study showed that alcoholic extract of Nigella sativa seed especially in higher doses could increase fertility potential, LH and testosterone concentration in male rats.
Indexed as
Identifiers
25246898PMC4165954What OpenQuestion holds
Registered trials
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