Evidence map›Paper›PMID 25246875›Full record

ArticleNanoscale research letters2014

Magnetic liposomes for colorectal cancer cells therapy by high-frequency magnetic field treatment.

Andri Hardiansyah, Li-Ying Huang, Ming-Chien Yang, Ting-Yu Liu, Sung-Chen Tsai, Chih-Yung Yang, Chih-Yu Kuo, Tzu-Yi Chan, Hui-Ming Zou, Wei-Nan Lian and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nanoscale research letters, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 107 citations in OpenAlex.

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  16. Magnetic systems for cancer immunotherapy.Acta pharmaceutica Sinica. B · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Andri HardiansyahDepartment of Materials Science and Engineering, National Taiwan University of Science and Technology, Taipei, 106, Taiwan.
Li-Ying HuangDepartment of Materials Science and Engineering, National Taiwan University of Science and Technology, Taipei, 106, Taiwan.
Ming-Chien YangDepartment of Materials Science and Engineering, National Taiwan University of Science and Technology, Taipei, 106, Taiwan.
Ting-Yu LiuDepartment of Materials Engineering, Ming Chi University of Technology, New Taipei City, 24301, Taiwan.
Sung-Chen TsaiInstitute of Microbiology and Immunology, School of Life Science, National Yang-Ming University, Taipei, 11221, Taiwan.
Chih-Yung YangInstitute of Microbiology and Immunology, School of Life Science, National Yang-Ming University, Taipei, 11221, Taiwan.
Chih-Yu KuoInstitute of Polymer Science and Engineering, National Taiwan University, Taipei, 106, Taiwan.
Tzu-Yi ChanDepartment of Materials Engineering, Ming Chi University of Technology, New Taipei City, 24301, Taiwan.
Hui-Ming ZouDepartment of Materials Engineering, Ming Chi University of Technology, New Taipei City, 24301, Taiwan.
Wei-Nan LianInstitute of Microbiology and Immunology, School of Life Science, National Yang-Ming University, Taipei, 11221, Taiwan.
Chi-Hung LinInstitute of Microbiology and Immunology, School of Life Science, National Yang-Ming University, Taipei, 11221, Taiwan.
Ming Chi University of Technology · TWNational Taiwan University of Science and Technology · TWNational Yang Ming Chiao Tung University · TWNational Yang Ming Chiao Tung University · TWNational Taiwan University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this study, we developed the cancer treatment through the combination of chemotherapy and thermotherapy using doxorubicin-loaded magnetic liposomes. The citric acid-coated magnetic nanoparticles (CAMNP, ca. 10 nm) and doxorubicin were encapsulated into the liposome (HSPC/DSPE/cholesterol = 12.5:1:8.25) by rotary evaporation and ultrasonication process. The resultant magnetic liposomes (ca. 90 to 130 nm) were subject to characterization including transmission electron microscopy (TEM), dynamic light scattering (DLS), X-ray diffraction (XRD), zeta potential, Fourier transform infrared (FTIR) spectrophotometer, and fluorescence microscope. In vitro cytotoxicity of the drug carrier platform was investigated through 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay using L-929 cells, as the mammalian cell model. In vitro cytotoxicity and hyperthermia (inductive heating) studies were evaluated against colorectal cancer (CT-26 cells) with high-frequency magnetic field (HFMF) exposure. MTT assay revealed that these drug carriers exhibited no cytotoxicity against L-929 cells, suggesting excellent biocompatibility. When the magnetic liposomes with 1 μM doxorubicin was used to treat CT-26 cells in combination with HFMF exposure, approximately 56% cells were killed and found to be more effective than either hyperthermia or chemotherapy treatment individually. Therefore, these results show that the synergistic effects between chemotherapy (drug-controlled release) and hyperthermia increase the capability to kill cancer cells.

Indexed as

Colorectal cancerDrug controlled releaseHigh-frequency magnetic fieldLiposomesMagnetic nanoparticle

Identifiers

PMID25246875
PMCPMC4169134
OpenAlexW2104648092

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.