Evidence map›Paper›PMID 25246833›Full record

ArticleThe Malaysian journal of medical sciences : MJMS2014

Histopathological Study of the Lungs of Mice Receiving Human Secretory IgA and Challenged with Mycobacterium tuberculosis.

Nadine Alvarez, Juan Francisco Infante, Reinier Borrero, Dulce Mata, Jorge Barrios- Payan, Md Murad Hossain, Norazmi Mohd Nor, María Elena Sarmiento, Rogelio Hernandez-Pando, Armando Acosta

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in The Malaysian journal of medical sciences : MJMS, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. SIgA in various pulmonary diseases.European journal of medical research · 2023
    Review
  2. B in TB: B Cells as Mediators of Clinically Relevant Immune Responses in Tuberculosis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2015
    Review
  3. Evaluation ofIndian journal of pharmacology
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Nadine AlvarezDepartment of Molecular Biology, Finlay Institute, Center of Research-Production of Vaccines, Ave. 27 No. 19805, La Lisa, Ciudad de la Habana, Cuba. AP. 16017, CP11600.
Juan Francisco InfanteDepartment of Molecular Biology, Finlay Institute, Center of Research-Production of Vaccines, Ave. 27 No. 19805, La Lisa, Ciudad de la Habana, Cuba. AP. 16017, CP11600.
Reinier BorreroDepartment of Molecular Biology, Finlay Institute, Center of Research-Production of Vaccines, Ave. 27 No. 19805, La Lisa, Ciudad de la Habana, Cuba. AP. 16017, CP11600.
Dulce MataExperimental Pathology Section, Department of Pathology, National Institute of Medical Sciences and Nutrition "Salvador Zubirán", Mexico.
Jorge Barrios- PayanExperimental Pathology Section, Department of Pathology, National Institute of Medical Sciences and Nutrition "Salvador Zubirán", Mexico.
Md Murad HossainSchool of Health Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia.
Norazmi Mohd NorSchool of Health Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia.
María Elena SarmientoDepartment of Molecular Biology, Finlay Institute, Center of Research-Production of Vaccines, Ave. 27 No. 19805, La Lisa, Ciudad de la Habana, Cuba. AP. 16017, CP11600.
Rogelio Hernandez-PandoExperimental Pathology Section, Department of Pathology, National Institute of Medical Sciences and Nutrition "Salvador Zubirán", Mexico.
Armando AcostaDepartment of Molecular Biology, Finlay Institute, Center of Research-Production of Vaccines, Ave. 27 No. 19805, La Lisa, Ciudad de la Habana, Cuba. AP. 16017, CP11600.
Universiti Sains Malaysia · MY

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHumoral and cellular immune responses are associated with protection against extracellular and intracellular pathogens, respectively. In the present study, we evaluated the effect of receiving human secretory immunoglobulin A (hsIgA) on the histopathology of the lungs of mice challenged with virulent Mycobacterium tuberculosis.

methodsThe hsIgA was purified from human colostrum and administered to Balb/c mice by the intranasal route prior to infection with M. tuberculosis or in a pre-incubated formulation with mycobacteria, with the principal aim to study its effect on qualitative pulmonary histopathology.

resultsThe intranasal administration of hsIgA and the pre-incubation of mycobacteria with this preparation was associated with the presence of organised granulomas with signs of immune activation and histological features related to efficient disease control. This effect was highly evident during the late stage of infection (60 days), as demonstrated by numerous organised granulomas with numerous activated macrophages in the lungs of treated mice.

conclusionThe administration of hsIgA to mice before intratracheal infection with M. tuberculosis or the pre-incubation of the bacteria with the antibody formulation induced the formation of well-organised granulomas and inflammatory lesions in lungs compared with non-treated animals which correlates with the protective effect already demonstrated by these antibody formulations.

Indexed as

colostrumsMycobacterium tuberculosissecretory immunoglobulin A

Identifiers

PMID25246833
PMCPMC4163556
OpenAlexW258202903

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.