ReviewNeuropsychiatric disease and treatment2014
Yokukan-san: a review of the evidence for use of this Kampo herbal formula in dementia and psychiatric conditions.
Review in Neuropsychiatric disease and treatment, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A Review of the Clinical Evidence for Complementary and Alternative Medicine in Huntington's Disease.Tremor and other hyperkinetic movements (New York, N.Y.) · 2019Pooled it
- Traditional Chinese medicine Jia Wei Gui Pi Tang improves behavioural and psychological symptoms of dementia and favourable positive emotions in patients.Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society · 2023Trial
- Effectiveness and safety of traditional Chinese therapies intreating patients with amyotrophic lateral sclerosis: a protocol for systematic review and meta-analysis.Frontiers in neurology · 2024Article
- Influence of Yokukansan on the refractive index of neuroblastoma cells.Biomedical optics express · 2023Article
- Temporal Changes in Brain Perfusion in a Patient with Myoclonus and Ataxia Syndrome Associated with COVID-19.Internal medicine (Tokyo, Japan) · 2022Article
- Preventive effect of Ninjin-yoei-to, a Kampo medicine, on amyloid βExperimental animals · 2021Article
- Impact of Pharmacotherapy on Insomnia in Patients with Alzheimer's Disease.Drugs & aging · 2021Review
- Effects of Combined Bushen Zhichan Recipe and Levodopa in a Rodent Model of Parkinson Disease: Potential Mechanisms.Medical science monitor : international medical journal of experimental and clinical research · 2020Article
- Traditional Oriental Medicines and Alzheimer's Disease.Aging and disease · 2019Review
- Yokukansan Alleviates Cancer Pain by Suppressing Matrix Metalloproteinase-9 in a Mouse Bone Metastasis Model.Evidence-based complementary and alternative medicine : eCAM · 2019Article
- The Kampo medicine Yokukansan (YKS) enhances nerve growth factor (NGF)-induced neurite outgrowth in PC12 cells.Bosnian journal of basic medical sciences · 2018Article
- Herbal Medicine Ninjin'yoeito in the Treatment of Sarcopenia and Frailty.Frontiers in nutrition · 2018Review
- Randomized phase II study of TJ-54 (Yokukansan) for postoperative delirium in gastrointestinal and lung malignancy patients.Molecular and clinical oncology · 2017Article
- Increased EphA4-ephexin1 signaling in the medial prefrontal cortex plays a role in depression-like phenotype.Scientific reports · 2017Article
- Perception and attitude of medical doctors in Dhaka, Bangladesh, with regard to Ayurvedic medicine.Nagoya journal of medical science · 2017Article
- Yokukansan enhances the proliferation of B65 neuroblastoma.Journal of traditional and complementary medicine · 2017Article
- The Traditional Medicine and Modern Medicine from Natural Products.Molecules (Basel, Switzerland) · 2016Review
- Perceptions of Ayurvedic medicine by citizens in Dhaka, Bangladesh.Nagoya journal of medical science · 2016Article
- Role of EphA4 signaling in the pathogenesis of amyotrophic lateral sclerosis and therapeutic potential of traditional Chinese medicine rhynchophylline.Psychopharmacology · 2015Article
- Lifestyle Medicine and Japan's Longevity Miracle.American journal of lifestyle medicineArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Japanese traditional herbal medicine (Kampo) has its origins in traditional Chinese medicine (TCM). It was introduced to Japan in the middle of the sixth century and has evolved over the past 1,400 years after combining with Japan's original folk remedies. While it retains some similarities to TCM, Kampo has evolved in Japan, resulting in a system of medicine that has many differences from TCM. Kampo medicine is considered to be very safe; in Japan, Kampo herbal formulas are manufactured by licensed pharmaceutical companies, prescribed by Western-trained medical doctors (usually as a freeze-dried extract), and have quality control standards similar to those of prescription drugs. The present study examined Yokukan-san (Yi-Gan San in TCM), a Kampo formula that has been used empirically in Japan for more than 400 years. Accumulating clinical trials have demonstrated Yokukan-san's efficacy in treating patients with behavioral and psychological symptoms of dementia, which has resulted in the Japanese Society of Neurology listing it in the Japanese Guidelines for the Management of Dementia 2010. Efficacy in other diseases and conditions, such as sleep disorders, tardive dyskinesia, aggression, and impulsivity has also been reported. This article reviews both clinical and basic studies of Yokukan-san, with the goal of clarifying its clinical indications.
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