ArticleClinical interventions in aging2014
Application of creatinine- and/or cystatin C-based glomerular filtration rate estimation equations in elderly Chinese.
Article in Clinical interventions in aging, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 15 citations in OpenAlex.
- Glomerular filtration rate by different measures and albuminuria are associated with risk of frailty: the Rugao Longitudinal Ageing Study.Aging clinical and experimental research · 2022Article
- Large difference but high correlation between creatinine and cystatin C estimated glomerular filtration rate in Mesoamerican sugarcane cutters.Occupational and environmental medicine · 2022Article
- Comparison of Creatinine and Cystatin C to Estimate Renal Function in Geriatric and Frail Patients.Life (Basel, Switzerland) · 2022Article
- Efficacy and Safety of Nicorandil in Preventing Contrast-Induced Nephropathy after Elective Percutaneous Coronary Intervention: A Pooled Analysis of 1229 Patients.Journal of interventional cardiology · 2020Article
- Assessment of creatinine and cystatin C-based eGFR equations in Chinese older adults with chronic kidney disease.International urology and nephrology · 2018Article
- Accuracy of glomerular filtration rate estimationequations in patients with hematopathy.Journal of biomedical research · 2017Article
- Establishing the presence or absence of chronic kidney disease: Uses and limitations of formulas estimating the glomerular filtration rate.World journal of methodology · 2017Review
- Performance of the creatinine and cystatin C-based equations for estimation of GFR in Chinese patients with chronic kidney disease.Clinical and experimental nephrology · 2017Article
- Evaluation of glomerular filtration rate by different equations in Chinese elderly with chronic kidney disease.International urology and nephrology · 2017Article
- Comparison between a serum creatinine-and a cystatin C-based glomerular filtration rate equation in patients receiving amphotericin B.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2016Article
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6 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundNo conventional creatinine- or cystatin C-based glomerular filtration rate (GFR) estimation equation performed consistently outstandingly in elderly Chinese in our previous studies. This research aimed to further evaluate the performance of some recently proposed estimation equations based on creatinine and cystatin C, alone or combined, in this specific population. MATERIALS AND
methodsThe equations were validated in a population totaling 419 participants (median age 68 [range 60-94] years). The estimated GFR (eGFR) calculated separately by ten equations was compared with the reference GFR (rGFR) measured by the (99m)Tc-DTPA renal dynamic imaging method.
resultsMedian serum creatinine, cystatin C, and rGFR levels were 0.93 mg/L, 1.13 mg/L, and 74.20 mL/min/1.73 m(2), respectively. The Chinese population-developed creatinine- and cystatin C-based (Cscr-cys) equation yielded the least median absolute difference (8.81 vs range 9.53-16.32, P<0.05, vs the Chronic Kidney Disease Epidemiology Collaboration serum creatinine equation), the highest proportion of eGFR within 15% and 30% of rGFR (P15 and P30, 55.13 and 85.44, P<0.05 and P<0.01, vs the Chronic Kidney Disease Epidemiology Collaboration serum creatinine equation), and the lowest root mean square error (14.87 vs range 15.30-22.45) in the whole cohort. A substantial agreement of diagnostic consistency between eGFR and rGFR (with a kappa 0.61-0.80) was also observed with the Cscr-cys equation. Moreover, measures of performance in the Cscr-cys equation were consistent across normal to mildly injured GFR strata and individuals aged ≤ 80 years. Among all the Cscr-cys equations, the elderly Chinese-developed creatinine-based (CEscr) equation performed best in this specific population. Nevertheless, none of the equations achieved ideal manifestation in the moderately to severely GFR-injured group or in individuals aged ≥ 80 years.
conclusionThe Cscr-cys equation appeared to be optimal in elderly Chinese among the investigated equations. If cystatin C is not available, the CEscr equation is an acceptable alternative. A multicenter study with abundant subjects to develop an apposite formula for elderly Chinese is assumed to be essential.
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