Evidence map›Paper›PMID 25246692›Full record

Trial reportThe American journal of tropical medicine and hygiene2014

Efficacy and safety of arachidonic acid for treatment of Schistosoma mansoni-infected children in Menoufiya, Egypt.

Sahar Selim, Ola El Sagheer, Azza El Amir, Rashida Barakat, Kevin Hadley, Maaike J Bruins, Rashika El Ridi

Open access · bronzeAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The American journal of tropical medicine and hygiene, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

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  9. Resistance ofJournal of parasitology research · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Sahar SelimDepartment of Parasitology, National Liver Institute, Menoufiya University, Shebin El-Kom, Menoufiya, Egypt; Zoology Department, Faculty of Science, Cairo University, Cairo, Egypt; Tropical Health Department, High Institute of Public Health, Alexandria University, Alexandria, Egypt; Human Evidence Department, DSM North America, Columbia, Maryland; Research and Development Department, DSM Biotechnology Center, Delft, The Netherlands.
Ola El SagheerDepartment of Parasitology, National Liver Institute, Menoufiya University, Shebin El-Kom, Menoufiya, Egypt; Zoology Department, Faculty of Science, Cairo University, Cairo, Egypt; Tropical Health Department, High Institute of Public Health, Alexandria University, Alexandria, Egypt; Human Evidence Department, DSM North America, Columbia, Maryland; Research and Development Department, DSM Biotechnology Center, Delft, The Netherlands.
Azza El AmirDepartment of Parasitology, National Liver Institute, Menoufiya University, Shebin El-Kom, Menoufiya, Egypt; Zoology Department, Faculty of Science, Cairo University, Cairo, Egypt; Tropical Health Department, High Institute of Public Health, Alexandria University, Alexandria, Egypt; Human Evidence Department, DSM North America, Columbia, Maryland; Research and Development Department, DSM Biotechnology Center, Delft, The Netherlands.
Rashida BarakatDepartment of Parasitology, National Liver Institute, Menoufiya University, Shebin El-Kom, Menoufiya, Egypt; Zoology Department, Faculty of Science, Cairo University, Cairo, Egypt; Tropical Health Department, High Institute of Public Health, Alexandria University, Alexandria, Egypt; Human Evidence Department, DSM North America, Columbia, Maryland; Research and Development Department, DSM Biotechnology Center, Delft, The Netherlands.
Kevin HadleyDepartment of Parasitology, National Liver Institute, Menoufiya University, Shebin El-Kom, Menoufiya, Egypt; Zoology Department, Faculty of Science, Cairo University, Cairo, Egypt; Tropical Health Department, High Institute of Public Health, Alexandria University, Alexandria, Egypt; Human Evidence Department, DSM North America, Columbia, Maryland; Research and Development Department, DSM Biotechnology Center, Delft, The Netherlands.
Maaike J BruinsDepartment of Parasitology, National Liver Institute, Menoufiya University, Shebin El-Kom, Menoufiya, Egypt; Zoology Department, Faculty of Science, Cairo University, Cairo, Egypt; Tropical Health Department, High Institute of Public Health, Alexandria University, Alexandria, Egypt; Human Evidence Department, DSM North America, Columbia, Maryland; Research and Development Department, DSM Biotechnology Center, Delft, The Netherlands.
Rashika El RidiDepartment of Parasitology, National Liver Institute, Menoufiya University, Shebin El-Kom, Menoufiya, Egypt; Zoology Department, Faculty of Science, Cairo University, Cairo, Egypt; Tropical Health Department, High Institute of Public Health, Alexandria University, Alexandria, Egypt; Human Evidence Department, DSM North America, Columbia, Maryland; Research and Development Department, DSM Biotechnology Center, Delft, The Netherlands rashika@mailer.eun.eg.
Menoufia University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Arachidonic acid (ARA), an omega-6 fatty acid, kills juvenile and adult schistosomes in vitro and displays highly significant and safe therapeutic effects in mice and hamsters infected with Schistosoma mansoni or S. haematobium. This study aims to examine the efficacy and safety of ARA in treatment of school-age children infected with S. mansoni. In total, 66 S. mansoni-infected schoolchildren (20-23 children/study arm) received a single dose of 40 mg/kg praziquantel (PZQ), ARA (10 mg/kg per day for 15 days), or PZQ combined with ARA. The children were examined before and after treatment for worm egg counts in stool and blood biochemical and immunological parameters. ARA proved to be as efficacious as PZQ in treatment of schoolchildren with low infection intensity (78% and 85% cure rates, respectively). For moderate-intensity infection, the ARA and PZQ combination led to 100% cure rate. Biochemical, hematological, and immunological parameters were either unchanged or ameliorated after ARA therapy.

Indexed as

AdolescentAnimalsArachidonic AcidChildCholesterol, HDLCholesterol, LDLDose-Response Relationship, DrugEgyptFecesFemaleHumansInterferon-gammaInterleukin-10MaleParasite Egg CountPraziquantelArachidonic AcidCholesterol, HDLCholesterol, LDLIFNG protein, humanIL10 protein, humanInterferon-gammaInterleukin-10PraziquantelTriglycerides

Identifiers

PMID25246692
PMCPMC4228895
OpenAlexW2318808300

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.