Evidence map›Paper›PMID 25246515›Full record

ArticleThe EMBO journal2014

Shigella hacks host immune responses by reprogramming the host epigenome.

Hiroshi Ashida, Chihiro Sasakawa

Abstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in The EMBO journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Macrophages Infected by a Pathogen and a Non-pathogen Spotted Fever GroupFrontiers in cellular and infection microbiology · 2019
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Hiroshi AshidaDivision of Bacterial Infection Biology, Institute of Medical Science, University of Tokyo, Minato-ku Tokyo, Japan.
Chihiro SasakawaDivision of Bacterial Infection Biology, Institute of Medical Science, University of Tokyo, Minato-ku Tokyo, Japan Nippon Institute for Biological Science, Ome Tokyo, Japan Medical Mycology Research Center, Chiba University, Chuo-ku Chiba, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bacterial pathogens alter host transcriptional programs to promote infection. Shigella OspF is an essential virulence protein with a unique phosphothreonine lyase activity. A new study in The EMBO Journal (Harouz et al, 2014) reveals a novel function of OspF: targeting of heterochromatin protein 1γ (HP1γ) and downregulation of a subset of immune genes. These results illustrate how bacterial pathogens exploit epigenetic modifications to counteract host immune responses.

Indexed as

TranscriptomeAnimalsBacterial Outer Membrane ProteinsCarbon-Oxygen LyasesChromobox Protein Homolog 5Chromosomal Proteins, Non-HistoneDysentery, BacillaryEnterocolitisShigella flexneriBacterial Outer Membrane ProteinsCarbon-Oxygen LyasesChromobox Protein Homolog 5Chromosomal Proteins, Non-Histone

Identifiers

PMID25246515
PMCPMC4282568

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.