ArticleMolecular and cellular biology1989
Differential transcription of exon 1 of the human c-fms gene in placental trophoblasts and monocytes.
Article in Molecular and cellular biology, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 89 citations in OpenAlex.
- Regulation of human trophoblast gene expression by endogenous retroviruses.Nature structural & molecular biology · 2023Article
- CSF1R as a Therapeutic Target in Bone Diseases: Obvious but Not so Simple.Current osteoporosis reports · 2022Review
- Regulation of Embryonic and Postnatal Development by the CSF-1 Receptor.Current topics in developmental biology · 2017Review
- Technical Advance: Transcription factor, promoter, and enhancer utilization in human myeloid cells.Journal of leukocyte biology · 2015Article
- CSF-1 receptor signaling in myeloid cells.Cold Spring Harbor perspectives in biology · 2014Review
- Article
- Macrophages and CSF-1: implications for development and beyond.Organogenesis · 2013Review
- Derepression of an endogenous long terminal repeat activates the CSF1R proto-oncogene in human lymphoma.Nature medicine · 2010Article
- Differential transcription factor occupancy but evolutionarily conserved chromatin features at the human and mouse M-CSF (CSF-1) receptor loci.Nucleic acids research · 2003Article
- Epigenetic consequences of AML1-ETO action at the human c-FMS locus.The EMBO journal · 2003Article
- Transcription factor complex formation and chromatin fine structure alterations at the murine c-fms (CSF-1 receptor) locus during maturation of myeloid precursor cells.Genes & development · 2002Article
- Synergistic up-regulation of the myeloid-specific promoter for the macrophage colony-stimulating factor receptor by AML1 and the t(8;21) fusion protein may contribute to leukemogenesis.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- CCAAT enhancer-binding protein (C/EBP) and AML1 (CBF alpha2) synergistically activate the macrophage colony-stimulating factor receptor promoter.Molecular and cellular biology · 1996Article
- Identification of a region which directs the monocytic activity of the colony-stimulating factor 1 (macrophage colony-stimulating factor) receptor promoter and binds PEBP2/CBF (AML1).Molecular and cellular biology · 1994Article
- The macrophage transcription factor PU.1 directs tissue-specific expression of the macrophage colony-stimulating factor receptor.Molecular and cellular biology · 1994Article
- Characterization of the promoter region of the human c-kit proto-oncogene.Japanese journal of cancer research : Gann · 1993Article
- Expression of mRNA encoding the macrophage colony-stimulating factor receptor (c-fms) is controlled by a constitutive promoter and tissue-specific transcription elongation.Molecular and cellular biology · 1993Article
- A colony-stimulating factor 1 (CSF-1) receptor/platelet-derived growth factor-beta receptor gene fusion confers CSF-1 independence and tumorigenicity on a c-myc-immortalized monocyte cell line.Molecular and cellular biology · 1992Article
- Coexpression of the genes for platelet-derived growth factor B-chain receptor and macrophage colony-stimulating factor 1 receptor during monocytic differentiation.Proceedings of the National Academy of Sciences of the United States of America · 1991Article
- New nucleotide sequence data on the EMBL File Server.Nucleic acids research · 1989Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Structural analysis of the 5' end of the human c-fms gene revealed that a large intron of about 25 kilobases separates an upstream noncoding exon (exon 1) from the signal peptide-containing exon (exon 2). Northern (RNA) blot analysis, S1 nuclease mapping, and primer extensions showed that exon 1 is transcribed in placenta but not in cells of the monocytic lineage. This is due to the differential usage of promoters, separated by approximately 25 kilobases, in a cell-specific manner. One major c-fms transcript was observed in U-937 cells, whereas multiple initiation sites for transcription appeared to be utilized in placental cells. Nucleotide sequence comparisons showed that the 3' end of the human platelet-derived growth factor receptor gene lies approximately 350 base pairs upstream of the major initiation sites for c-fms transcription in placental trophoblasts.
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