Evidence map›Paper›PMID 25246335›Full record

ArticleNephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association2015

The relationship between thyroid function and estimated glomerular filtration rate in patients with chronic kidney disease.

Connie M Rhee, Kamyar Kalantar-Zadeh, Elani Streja, Juan-Jesus Carrero, Jennie Z Ma, Jun L Lu, Csaba P Kovesdy

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03191188 (A Pilot Feasibility Trial of Thyroid Hormone Replacement in Dialysis Patients), which is not on this map. Cited by 62 papers.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03191188 naunknown statusnot on this mapstarted 2017, after this paper: background citation

A Pilot Feasibility Trial of Thyroid Hormone Replacement in Dialysis Patients

TypeinterventionalSponsorUniversity of California, IrvineRan2017 to 2021Enrolled96ConditionsThyroid Disease, Kidney Diseases, ChronicArmsLevothyroxine Sodium, Placebo Oral Tablet
3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 110 citations in OpenAlex.

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  18. Kidney disease and thyroid dysfunction: the chicken or egg problem.Pediatric nephrology (Berlin, Germany) · 2022
    Review
  19. Article
  20. Review

2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Connie M RheeHarold Simmons Center for Chronic Disease Research and Epidemiology, Division of Nephrology and Hypertension, University of California Irvine Medical Center, Orange, CA, USA.
Kamyar Kalantar-ZadehHarold Simmons Center for Chronic Disease Research and Epidemiology, Division of Nephrology and Hypertension, University of California Irvine Medical Center, Orange, CA, USA.
Elani StrejaHarold Simmons Center for Chronic Disease Research and Epidemiology, Division of Nephrology and Hypertension, University of California Irvine Medical Center, Orange, CA, USA.
Juan-Jesus CarreroDivision of Nephrology, Karolinska Institutet, Stockholm, Sweden.
Jennie Z MaDivision of Nephrology, University of Virginia, Charlottesville, VA, USA.
Jun L LuDivision of Nephrology, University of Tennessee Health Science Center, Memphis, TN, USA.
Csaba P KovesdyDivision of Nephrology, University of Tennessee Health Science Center, Memphis, TN, USA Division of Nephrology, Memphis Veterans Affairs Medical Center, Memphis, TN, USA.
University of California, Irvine Medical Center · USUniversity of Tennessee Health Science Center · USKarolinska Institutet · SEUniversity of Virginia · US

Funding

MALNUTRITION, DIET AND RACIAL DISPARITIES IN CKDK24DK091419 · NIDDK · UNIVERSITY OF CALIFORNIA-IRVINE · PI KALANTAR-ZADEH, KAMYAR · 2011 to 2020
$1.8M
Examining Racial and Cardiovascular Paradoxes in Chronic Kidney DiseaseR01DK078106 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KALANTAR-ZADEH, KAMYAR · 2007 to 2011
$1.1M
Hypothyroidism, Cardiovascular Health, and Survival in Kidney DiseaseK23DK102903 · NIDDK · UNIVERSITY OF CALIFORNIA-IRVINE · PI RHEE, CONNIE MEEYOUNG · 2014 to 2018
$955k
HSRD VA SDR 02-237NIDDK NIH HHS K23 DK102903NIDDK NIH HHS K23-DK102903NIDDK NIH HHS K24 DK091419NIDDK NIH HHS K24-DK091419NIDDK NIH HHS R01 DK078106NIDDK NIH HHS R01-DK078106
6 · The paper itself

Abstract

backgroundRecent studies have shown an increasing risk of hypothyroidism with incrementally lower estimated glomerular filtration rate (eGFR) in cohorts comprised of patients with normal to mildly impaired kidney function. We sought to confirm these findings in a nationally representative cohort of Veterans Affairs patients with moderate-to-severe chronic kidney disease (CKD).

methodsThis study examined the association between kidney function and hypothyroidism among 461 607 veterans with Stage 3 to 5 CKD who underwent repeated measurements of serum creatinine and thyrotropin (TSH) at identical time points between October 2004 and September 2006. Kidney function was defined by eGFR using the Chronic Kidney Disease Epidemiology Collaboration formula. In primary analyses, the association between eGFR and hypothyroidism (defined as serum TSH > 5 mIU/L and/or receipt of thyroid hormone supplementation) was estimated using multivariable random effects logistic regression. In secondary analyses, the association between eGFR and serum TSH level was estimated using multivariable random effects linear regression.

resultsAt baseline, 68.9, 25.5, 5.3 and 0.3% of patients had Stage 3A, 3B, 4 and 5 CKD, respectively. For every 10 mL/min/1.73 m(2) lower eGFR, there was an 18% higher risk of hypothyroidism: adjusted odds ratio 1.18 [95% confidence interval (CI) 1.17-1.20, P < 0.001]. In secondary analyses, we observed that a 10 mL/min/1.73 m(2) lower eGFR was associated with a 0.11 mIU/L higher serum TSH (95% CI 0.10-0.11 mIU/L higher serum TSH, P < 0.001).

conclusionsIn a nationally representative cohort of patients with moderate-to-severe CKD, there is an inverse association between eGFR and risk of hypothyroidism.

Indexed as

AgedCohort StudiesFemaleGlomerular Filtration RateHumansHypothyroidismKidney Function TestsLinear ModelsMaleOdds RatioRenal Insufficiency, ChronicThyroid Function TestsThyroid GlandThyrotropinUnited StatesVeteransThyrotropinchronic kidney diseaseestimated glomerular filtration ratehypothyroidthyroid

Identifiers

PMID25246335
PMCPMC4309193
OpenAlexW2146269367

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.