ArticleParkinsonism & related disorders2014
Comparison of voluntary and reflex cough effectiveness in Parkinson's disease.
Article in Parkinsonism & related disorders, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Guideline
- Breathe, Eat, Talk: Three Essential Ingredients to Quality-of-Life Outcomes in Movement Disorders.Movement disorders clinical practice · 2026Review
- Association between Perceived Dysphagia Symptoms and Swallowing Physiology in Parkinson's Disease.Movement disorders clinical practice · 2025Article
- Nursing Process Related to the Nursing Focus "Airway Clearance": A Scoping Review.Nursing reports (Pavia, Italy) · 2024Article
- Deglutologist Practices and Perceptions of the Penetration-Aspiration Scale: A Survey Study.Dysphagia · 2024Article
- TBscreen: A passive cough classifier for tuberculosis screening with a controlled dataset.Science advances · 2024Article
- Hypotussic cough in persons with dysphagia: biobehavioral interventions and pathways to clinical implementation.Frontiers in rehabilitation sciences · 2024Review
- Assessment of the Sensitivity of the Vocal Tract in Parkinson Disease by Nasal Video Endoscopy.International archives of otorhinolaryngology · 2023Article
- Dysphagia in Parkinson Disease: Part I - Pathophysiology and Diagnostic Practices.Current physical medicine and rehabilitation reports · 2023Article
- Examining the Influence of Chemosensation on Laryngeal Health and Disorders.Journal of voice : official journal of the Voice Foundation · 2023Review
- Perceptual and qualitative voice alterations detected by GIRBAS in patients with Parkinson's disease: is there a relation with lung function and oxygenation?Aging clinical and experimental research · 2023Observational
- Assessment of cough in head and neck cancer patients at risk for dysphagia-An overview.Cancer reports (Hoboken, N.J.) · 2021Review
- Article
- Reliability of voluntary cough assessments using respiratory flow waveform.Journal of physical therapy science · 2020Article
- Article
- Disordered voluntary cough as freezing phenomenon in parkinsonism.Journal of physical therapy science · 2017Article
- Reflex Cough and Disease Duration as Predictors of Swallowing Dysfunction in Parkinson's Disease.Dysphagia · 2016Article
- To Cough or Not to Cough? Examining the Potential Utility of Cough Testing in the Clinical Evaluation of Swallowing.Current physical medicine and rehabilitation reports · 2016Article
- Dysphagia Practice in 2035: Beyond Fluorography, Thickener, and Electrical Stimulation.Seminars in speech and language · 2016Article
- Analysis of Clinicians' Perceptual Cough Evaluation.Dysphagia · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
introductionMultiple airway protective mechanisms are impacted with Parkinson's disease (PD), including swallowing and cough. Cough serves to eject material from the lower airways, and can be produced voluntarily (on command) and reflexively in response to aspirate material or other airway irritants. Voluntary cough effectiveness is reduced in PD however it is not known whether reflex cough is affected as well. The goal of this study was to compare the effectiveness between voluntary and reflex cough in patients with idiopathic PD.
methodsTwenty patients with idiopathic PD participated. Cough airflow data were recorded via facemask in line with a pneumotachograph. A side delivery port connected the nebulizer for delivery of capsaicin, which was used to induce cough. Three voluntary coughs and three reflex coughs were analyzed from each participant. A two-way repeated measures analysis of variance was used to compare voluntary versus reflex cough airflow parameters.
resultsSignificant differences were found for peak expiratory flow rate (PEFR) and cough expired volume (CEV) between voluntary and reflex cough. Specifically, both PEFR and CEV were reduced for reflex as compared to voluntary cough.
conclusionCough PEFR and CEV are indicative of cough effectiveness in terms of the ability to remove material from the lower airways. Differences between these two cough types likely reflect differences in the coordination of the respiratory and laryngeal subsystems. Clinicians should be aware that evaluation of cough function using voluntary cough tasks overestimates the PEFR and CEV that would be achieved during reflex cough in patients with PD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.