ReviewJournal of assisted reproduction and genetics2015
Iron and copper in male reproduction: a double-edged sword.
Review in Journal of assisted reproduction and genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
77 citing papers in PubMed, 1 synthesis or guideline pooled it, 194 citations in OpenAlex.
- The effect of obesity interventions on male fertility: a systematic review and meta-analysis.Human reproduction update · 2026Pooled it
- The role of iron in normal and impaired testicular function.Andrology · 2026Review
- Dietary patterns and testosterone balance: a review of clinical data and perspectives.Journal of advanced research · 2026Review
- Mendelian Randomization Analysis Reveals Iron as a Potential Contributor to Male Infertility.The world journal of men's health · 2026Article
- Metals/Metalloids Profile in Seminal Plasma/Serum of Patients with Asthenozoospermia/Oligozoospermia: Correlation with Semen Quality.Biological trace element research · 2026Article
- Oxidative Stress-Related Programmed Cell Death in Male Infertility: Focussing on Ferroptosis.Journal of cellular and molecular medicine · 2026Review
- Crossroads of iron, copper, and zinc in cancer: a paradox of toxicity and therapy.Molecular biology reports · 2026Review
- CD71 defines functionally active spermatogonial stem cells with enhanced transplantation potential in mouse testes.Animal cells and systems · 2026Article
- Extracellular Vesicles, Nutrient Balance, and Redox Metabolism During Epididymal Sperm Maturation: A Perspective on the Complexity of Intercellular Interplay.Advances in anatomy, embryology, and cell biology · 2026Review
- Associations of seminal plasma metal mixtures with sperm quality parameters and exploratory mediation analysis of urinary oxidative stress biomarkers: a cross-sectional study from the RHCC-AC preconception cohort.Frontiers in endocrinology · 2026Article
- Article
- Benzalkonium Chloride-Coated Iron Oxide Nanoparticles: Cytotoxic Potential on Murine Leydig Cells (TM3).ACS omega · 2025Article
- The Risk of Transmission of Genetic Prion Diseases is Greater Than 50.European journal of neurology · 2025Article
- Mechanism and regulation of iron absorption throughout the life cycle.Journal of advanced research · 2025Review
- Leveraging electronic health records from two hospital systems identifies male infertility-associated comorbidities across time.Communications medicine · 2025Article
- Iron biomarkers in men with infertility are associated with sperm DNA hydroxymethylation and cumulative live birth rates: a prospective study.Journal of translational medicine · 2025Article
- A multi-omics approach reveals that lotus root polysaccharide iron ameliorates iron deficiency-induced testicular damage by activating PPARγ to promote steroid hormone synthesis.Journal of advanced research · 2025Article
- The importance of zinc, copper and manganese and their impact on growth, immunity and fertility of male cattle: a review.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2025Review
- Unveiling the nexus between environmental exposures and testicular damages: revelations from autophagy and oxidative stress imbalance.Cell death discovery · 2025Review
- Immunohistochemical Detection of Iron-Related Proteins in Sertoli Cell-Only Patterns in Canine Testicular Lesions.Animals : an open access journal from MDPI · 2025Article
17 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Iron and copper are essential trace nutrients playing important roles in general health and fertility. However, both elements are highly toxic when accumulating in large quantities. Their direct or indirect impact on the structure and function of male gonads and gametes is not completely understood yet. Excess or deficiency of either element may lead to defective spermatogenesis, reduced libido, and oxidative damage to the testicular tissue and spermatozoa, ultimately leading to fertility impairment. This review will detail the complex information currently available on the dual roles iron and copper play in male reproduction.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.