ArticleInfection and immunity2014
FNR regulates expression of important virulence factors contributing to pathogenicity of uropathogenic Escherichia coli.
Article in Infection and immunity, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Review
- Fumarate and nitrate reduction regulator (FNR) modulates hypermucoviscosity and virulence in hypervirulentVirulence · 2025Article
- Advances and Challenges inVaccines · 2025Review
- A comprehensive review of the pathogenic mechanisms ofFrontiers in microbiology · 2025Review
- Deletion of both anaerobic regulator genes fnr and narL compromises the colonization of Salmonella Typhimurium in mice model.World journal of microbiology & biotechnology · 2024Article
- Type 1 fimbria and P pili: regulatory mechanisms of the prototypical members of the chaperone-usher fimbrial family.Archives of microbiology · 2024Review
- Nitric oxide is a host cue for Salmonella Typhimurium systemic infection in mice.Communications biology · 2023Article
- Adaptive strategies of uropathogenic Escherichia coli CFT073: from growth in lab media to virulence during host cell adhesion.International microbiology : the official journal of the Spanish Society for Microbiology · 2022Article
- Genes Differentially Expressed by Haemophilus ducreyi during Anaerobic Growth Significantly Overlap Those Differentially Expressed during Experimental Infection of Human Volunteers.Journal of bacteriology · 2022Article
- Global transcriptional regulator FNR regulates the pyruvate cycle and proton motive force to play a role in aminoglycosides resistance ofFrontiers in microbiology · 2022Article
- Article
- RegAB Homolog of Burkholderia pseudomallei is the Master Regulator of Redox Control and involved in Virulence.PLoS pathogens · 2021Article
- Fnr Negatively Regulates Prodigiosin Synthesis inFrontiers in microbiology · 2021Article
- Article
- Article
- Flexible Metabolism and Suppression of Latent Enzymes Are Important forJournal of bacteriology · 2019Article
- Proteomic Analysis of FNR-Regulated Anaerobiosis in Salmonella Typhimurium.Journal of the American Society for Mass Spectrometry · 2019Article
- Virulence factors and antimicrobial resistance in uropathogenic Escherichiacoli strains isolated from cystitis and pyelonephritisTurkish journal of medical sciences · 2019Article
- Genetic diversity and antibiotic susceptibility of uropathogenicInfection and drug resistance · 2019Article
- Regulation of hemolysin in uropathogenic Escherichia coli fine-tunes killing of human macrophages.Virulence · 2018Article
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10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Uropathogenic Escherichia coli (UPEC) is responsible for the majority of urinary tract infections (UTIs), which are some of the world's most common bacterial infections of humans. Here, we examined the role of FNR (fumarate and nitrate reduction), a well-known global regulator, in the pathogenesis of UPEC infections. We constructed an fnr deletion mutant of UPEC CFT073 and compared it to the wild type for changes in virulence, adherence, invasion, and expression of key virulence factors. Compared to the wild type, the fnr mutant was highly attenuated in the mouse model of human UTI and showed severe defects in adherence to and invasion of bladder and kidney epithelial cells. Our results showed that FNR regulates motility and multiple virulence factors, including expression of type I and P fimbriae, modulation of hemolysin expression, and expression of a novel pathogenicity island involved in α-ketoglutarate metabolism under anaerobic conditions. Our results demonstrate that FNR is a key global regulator of UPEC virulence and controls expression of important virulence factors that contribute to UPEC pathogenicity.
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