ArticleAnnals of the Royal College of Surgeons of England2014
The morbidity of negative appendicectomy.
Article in Annals of the Royal College of Surgeons of England, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06000020 (Leave or Laparoscopic Appendectomy With Normal Findings - a Regional Cohort Study), which is not on this map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Leave or Laparoscopic Appendectomy With Normal Findings - a Regional Cohort Study
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- The SIFIPAC/WSES/SICG/SIMEU guidelines for diagnosis and treatment of acute appendicitis in the elderly (2019 edition).World journal of emergency surgery : WJES · 2020Guideline
- Randomized control trial comparing an Alvarado Score-based management algorithm and current best practice in the evaluation of suspected appendicitis.World journal of emergency surgery : WJES · 2020Trial
- Diagnostic value of CAR, HALP, and SII for predicting complicated appendicitis: a reassessment of inflammatory indices.BMC surgery · 2026Observational
- Identifying novel indicators of non-technical skills derived from operative video annotation.The British journal of surgery · 2026Article
- Article
- Outcomes of laparoscopic appendectomy of a normally appearing appendix in children with suspected acute appendicitis: a tertiary care center experience.BMC pediatrics · 2025Article
- Parasitic appendicitis, what do we know?-a literature review.Translational gastroenterology and hepatology · 2025Review
- Is pelvic ultrasound useful in the clinical assessment and management of women with right iliac fossa pain? A single-centre retrospective study.Annals of the Royal College of Surgeons of England · 2024Article
- Patients' attitudes toward negative appendectomies and surgery for suspected appendicitis: a qualitative interview study.Surgical endoscopy · 2024Article
- Observation Safely Reduces the Use of the Computerized Tomography in Medium-to-Low-Risk Patients with Suspected Acute Appendicitis: Results of a Randomized Controlled Trial.Journal of clinical medicine · 2024Article
- Diagnostic value of laboratory parameters for complicated appendicitis: A two‑center study.Biomedical reports · 2024Article
- Risk factors for postoperative morbidity, prolonged length of stay and hospital readmission after appendectomy for acute appendicitis.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2023Article
- Outcomes of the Macroscopically Normal Appendix Left in Situ in Patients with Suspected Appendicitis.World journal of surgery · 2022Article
- COVID-19 opens the door for right iliac fossa pain treatment pathway.Annals of the Royal College of Surgeons of England · 2022Article
- Diagnostic Accuracy Rates of Appendicitis Scoring Systems for the Stratified Age Groups.Emergency medicine international · 2022Article
- Lipomatosis of appendix in a teenager.Clinical case reports · 2021Article
- Computerized tomography scan in acute appendicitis with eventual negative appendectomy.Journal of clinical and translational research · 2021Article
- Suspected appendicitis and COVID-19, a change in investigation and management-a multicentre cohort study.Langenbeck's archives of surgery · 2021Observational
- Morbidity after negative appendectomy: a single-centre experience on 627 cases.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2020Article
- Accuracy of Mean Platelet Volume (MPV) and Red Cell Distribution Width (RDW) for the Diagnosis of Acute Appendicitis: Evaluation of Possible New Biomarkers.Advanced journal of emergency medicine · 2020Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe increased use of diagnostic laparoscopy for management of right iliac fossa pain may have lowered the threshold for removing normal appendices, particularly as there is a perception that this practice carries little additional morbidity. The aim of this retrospective audit was to determine the negative appendicectomy rate after laparoscopic appendicectomy (LA) in our busy district hospital, and to compare the relative incidence and severity of complications after removal of an inflamed or non-inflamed appendix.
methodsAdult patients who underwent LA in 2011-2012 were identified from theatre registers. Histology results were reviewed to differentiate between inflamed and normal appendices. Postoperative complications and events following discharge were identified via electronic patient records. Complication severity was stratified using the Clavien-Dindo classification.
resultsOver 2 years, 467 LAs were performed, of which 143 (30.6%) were for normal appendices. Significantly more negative appendicectomies were performed in women (43%) than in men (17%) (p<0.0001). Complications were seen in 62 patients (13.3%). There was no significant difference between the complication rates for those who had an inflamed (16.6%) or non-inflamed (11.9%) appendix (p=0.141). Similarly, there was no difference in the severity of complications between these groups. Reoperation or invasive intervention was required after four negative appendicectomies (2.8%).
conclusionsLA carries a similar morbidity regardless of whether the appendix is inflamed. Negative appendicectomy should not be undertaken routinely during laparoscopy for right iliac fossa pain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.