ArticleHearing research2015
Longitudinal performance of an implantable vestibular prosthesis.
Article in Hearing research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Continuous vestibular implant stimulation partially restores eye-stabilizing reflexes.JCI insight · 2019Trial
- Vestibulocochlear implant (VCI) modulation improves mid and high frequency vestibulo-ocular reflex (VOR).Journal of neurology · 2026Article
- Review
- Article
- The Next Challenges of Vestibular Implantation in Humans.Journal of the Association for Research in Otolaryngology : JARO · 2023Review
- Vestibular prosthesis: from basic research to clinics.Frontiers in integrative neuroscience · 2023Review
- [Optimal design of neural modulation strategy of vestibular prosthesis].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2020Article
- The vestibular implant: Opinion statement on implantation criteria for research.Journal of vestibular research : equilibrium & orientation · 2020Review
- Interactions between Auditory and Vestibular Modalities during Stimulation with a Combined Vestibular and Cochlear Prosthesis.Audiology & neuro-otology · 2020Article
- Nonhuman primate vestibuloocular reflex responses to prosthetic vestibular stimulation are robust to pulse timing errors caused by temporal discretization.Journal of neurophysiology · 2019Article
- The Dynamics of Prosthetically Elicited Vestibulo-Ocular Reflex Function Across Frequency and Context in the Rhesus Monkey.Frontiers in neuroscience · 2018Article
- Nonhuman Primate Studies to Advance Vision Science and Prevent Blindness.ILAR journal · 2017Review
- Wireless inertial measurement of head kinematics in freely-moving rats.Scientific reports · 2016Article
- Recent Evidence About the Effectiveness of Vestibular Rehabilitation.Current treatment options in neurology · 2016Article
- Loss of Afferent Vestibular Input Produces Central Adaptation and Increased Gain of Vestibular Prosthetic Stimulation.Journal of the Association for Research in Otolaryngology : JARO · 2016Article
- Vestibular implantation and longitudinal electrical stimulation of the semicircular canal afferents in human subjects.Journal of neurophysiology · 2015Article
- Vestibular Implant Surgery: How to Deal With Obstructed Semicircular Canals-A Diagnostic and Surgical Guide.Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-facialeArticle
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Loss of vestibular function may be treatable with an implantable vestibular prosthesis that stimulates semicircular canal afferents with biphasic pulse trains. Several studies have demonstrated short-term activation of the vestibulo-ocular reflex (VOR) with electrical stimulation. Fewer long-term studies have been restricted to small numbers of animals and stimulation designed to produce adaptive changes in the electrically elicited response. This study is the first large consecutive series of implanted rhesus macaque to be studied longitudinally using brief stimuli designed to limit adaptive changes in response, so that the efficacy of electrical activation can be studied over time, across surgeries, canals and animals. The implantation of a vestibular prosthesis in animals with intact vestibular end organs produces variable responses to electrical stimulation across canals and animals, which change in threshold for electrical activation of eye movements and in elicited slow phase velocities over time. These thresholds are consistently lower, and the slow phase velocities higher, than those obtained in human subjects. The changes do not appear to be correlated with changes in electrode impedance. The variability in response suggests that empirically derived transfer functions may be required to optimize the response of individual canals to a vestibular prosthesis, and that this function may need to be remapped over time. This article is part of a Special Issue entitled <Lasker Award>.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.