ArticlePediatric nephrology (Berlin, Germany)2015
Is the serum level of salusin-β associated with hypertension and atherosclerosis in the pediatric population?
Article in Pediatric nephrology (Berlin, Germany), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 25 citations in OpenAlex.
- Can Serum Salusin-α and Salusin-β Serve as Biomarkers for Early Atherosclerotic Lesions in Obese Children?International journal of molecular sciences · 2025Article
- Overexpression of salusin‑β downregulates adipoR1 expression to prevent fatty acid oxidation in HepG2 cells.Molecular medicine reports · 2024Article
- A New Insight Into Pathophysiological Mechanism of Abdominal Aortic Aneurysm With Novel Parameters Salusin-β and Arterial Stiffness.Texas Heart Institute journal · 2022Article
- Current Knowledge of Selected Cardiovascular Biomarkers in Pediatrics: Kidney Injury Molecule-1, Salusin-α and -β, Uromodulin, and Adropin.Children (Basel, Switzerland) · 2022Review
- Salusin‑β participates in high glucose‑induced HK‑2 cell ferroptosis in aMolecular medicine reports · 2021Article
- A TOR2A Gene Product: Salusin-β Contributes to Attenuated Vasodilatation of Spontaneously Hypertensive Rats.Cardiovascular drugs and therapy · 2021Article
- Improvement of Vascular Function by Knockdown of Salusin-β in Hypertensive Rats via Nitric Oxide and Reactive Oxygen Species Signaling Pathway.Frontiers in physiology · 2021Article
- Salusin-The Journal of international medical research · 2020Article
- Salusin-β mediates tubular cell apoptosis in acute kidney injury: Involvement of the PKC/ROS signaling pathway.Redox biology · 2020Article
- Relationship of salusin-alpha and salusin-beta levels with atherosclerosis in patients undergoing haemodialysis.Singapore medical journal · 2019Article
- Identification and quantification of plasma free salusin-β, an endogenous parasympathomimetic peptide.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSalusins are recently identified endogenous bioactive peptides that have hypotensive and bradycardiac effects. Salusin-β is involved in the pathogenesis of human atherosclerosis.
methodsThis was a prospective cohort study of a young patient population with hypertension (HTN). Based on ambulatory blood pressure monitoring (ABPM), the adolescents were categorized into two groups, namely, a hypertensive group consisting of patients with essential (primary) HTN (HTN group) and a group consisting of patients with white-coat HTN [reference (R) group]. Correlations between serum salusin-β level and clinical, laboratory and ambulatory blood pressure (BP) variables were assessed.
resultsThe median salusin-β concentration was significantly higher in patients with essential HTN than in those with white-coat HTN (R group). Salusin-β was positively correlated with the body mass index Z-score, systolic and diastolic blood pressure (BP) from three independent measurements, mean systolic BP during the daytime, triglyceride (TG) level, and atherogenic index (TG/high-density lipoprotein-cholesterol ratio).
conclusionsThe results of this preliminary study suggest that salusin-β may play an important role in the pathogenesis of HTN in a young population. Further research should focus on the role of salusin-β in the mechanism of essential HTN and the assessment of possible correlations between salusin-β and other well-known markers of atherosclerosis in both teenagers and adults. This research should serve as a base for future studies in this field.
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