ArticlePlant physiology2014
Variation in sulfur and selenium accumulation is controlled by naturally occurring isoforms of the key sulfur assimilation enzyme ADENOSINE 5'-PHOSPHOSULFATE REDUCTASE2 across the Arabidopsis species range.
Article in Plant physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 66 citations in OpenAlex.
- Identification of Sulfate Transporter Genes inPlants (Basel, Switzerland) · 2025Article
- Comparison of linkage and association mapping in MAGIC lines identifies AtMTP3 as a new gene controlling natural variation in leaf zinc concentration in Arabidopsis.Journal of experimental botany · 2025Article
- Analysis of the quadruple lsu mutant reveals molecular determinants of the role of LSU proteins in sulfur assimilation in Arabidopsis.The Plant journal : for cell and molecular biology · 2024Article
- Adaptive modifications in plant sulfur metabolism over evolutionary time.Journal of experimental botany · 2024Review
- Traits linked to natural variation of sulfur content in Arabidopsis thaliana.Journal of experimental botany · 2024Article
- Natural Variation inPlants (Basel, Switzerland) · 2022Article
- Ionomic Approaches for Discovery of Novel Stress-Resilient Genes in Plants.International journal of molecular sciences · 2021Review
- A curated list of genes that affect the plant ionome.Plant direct · 2020Article
- QTL and candidate genes associated with leaf anion concentrations in response to phosphate supply in Arabidopsis thaliana.BMC plant biology · 2019Article
- Sulfation pathways from red to green.The Journal of biological chemistry · 2019Review
- The effect of desulfurization on the postharvest quality and sulfite metabolism in pulp of sulfitated "Feizixiao" Litchi (Food science & nutrition · 2019Article
- Functional and molecular characterization of the conserved Arabidopsis PUMILIO protein, APUM9.Plant molecular biology · 2019Article
- Linking genes with ecological strategies in Arabidopsis thaliana.Journal of experimental botany · 2019Review
- Comparative transcriptomics provides novel insights into the mechanisms of selenium tolerance in the hyperaccumulator plant Cardamine hupingshanensis.Scientific reports · 2018Article
- Article
- Selenium and Sulfur to Produce Allium Functional Crops.Molecules (Basel, Switzerland) · 2017Review
- Root morphology and seed and leaf ionomic traits in a Brassica napus L. diversity panel show wide phenotypic variation and are characteristic of crop habit.BMC plant biology · 2016Article
- Hormonal control of sulfate uptake and assimilation.Plant molecular biology · 2016Review
- Fine mapping and candidate gene analysis of an anthocyanin-rich gene, BnaA.PL1, conferring purple leaves in Brassica napus L.Molecular genetics and genomics : MGG · 2016Article
- Selenium accumulation by plants.Annals of botany · 2016Review
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Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
Abstract
Natural variation allows the investigation of both the fundamental functions of genes and their role in local adaptation. As one of the essential macronutrients, sulfur is vital for plant growth and development and also for crop yield and quality. Selenium and sulfur are assimilated by the same process, and although plants do not require selenium, plant-based selenium is an important source of this essential element for animals. Here, we report the use of linkage mapping in synthetic F2 populations and complementation to investigate the genetic architecture of variation in total leaf sulfur and selenium concentrations in a diverse set of Arabidopsis (Arabidopsis thaliana) accessions. We identify in accessions collected from Sweden and the Czech Republic two variants of the enzyme ADENOSINE 5'-PHOSPHOSULFATE REDUCTASE2 (APR2) with strongly diminished catalytic capacity. APR2 is a key enzyme in both sulfate and selenate reduction, and its reduced activity in the loss-of-function allele apr2-1 and the two Arabidopsis accessions Hodonín and Shahdara leads to a lowering of sulfur flux from sulfate into the reduced sulfur compounds, cysteine and glutathione, and into proteins, concomitant with an increase in the accumulation of sulfate in leaves. We conclude from our observation, and the previously identified weak allele of APR2 from the Shahdara accession collected in Tadjikistan, that the catalytic capacity of APR2 varies by 4 orders of magnitude across the Arabidopsis species range, driving significant differences in sulfur and selenium metabolism. The selective benefit, if any, of this large variation remains to be explored.
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