ArticleJournal of periodontal research2015
Ligature-induced peri-implantitis in mice.
Article in Journal of periodontal research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
20 citing papers in PubMed, 45 citations in OpenAlex.
- Methodological Evaluation of Micro-CT Analytical Parameters for Quantifying Bone Loss in a Murine Maxillary Peri-Implantitis Model.Dentistry journal · 2026Article
- Peri-implant inflammation increases the risk of osteonecrosis in mice treated with bisphosphonate.Journal of periodontology · 2025Article
- Murine Models in Oral Research: A Narrative Review of Experimental Approaches and Cardiovascular Implications.Biology · 2025Review
- Diabetes mellitus exacerbates inflammation in a murine model of ligature-induced peri-implantitis: A histological and microtomographic study.Journal of clinical periodontology · 2024Article
- Experimental models for peri-implant diseases: a narrative review.Clinical oral investigations · 2024Review
- A Standardized Rat Model to Study Peri-implantitis of Transmucosal Osseointegrated Implants.Biomaterials research · 2024Article
- Reprogramming mitochondrial metabolism of macrophages by miRNA-released microporous coatings to prevent peri-implantitis.Journal of nanobiotechnology · 2023Article
- A Model of Immediate Implant Placement to Evaluate Early Osseointegration in 129/Sv Diabetic Mice.The International journal of oral & maxillofacial implants · 2023Article
- Rodent peri-implantitis models: a systematic review and meta-analysis of morphological changes.Journal of periodontal & implant science · 2022Article
- Asperuloside Prevents Peri-Implantitis via Suppression of NF-κB and ERK1/2 on Rats.Pharmaceuticals (Basel, Switzerland) · 2022Article
- The Effects of NF-kB Inhibition with p65-TMD-Linked PTD on Inflammatory Responses at Peri-implantitis Sites.Inflammation · 2021Article
- Pre-Clinical Models in Implant Dentistry: Past, Present, Future.Biomedicines · 2021Review
- Evaluation of biofilm colonization on multi-part dental implants in a rat model.BMC oral health · 2021Article
- Mangiferin alleviates experimental peri-implantitis via suppressing interleukin-6 production and Toll-like receptor 2 signaling pathway.Journal of orthopaedic surgery and research · 2019Article
- An alternative, easy and reproducible method of stabilization and ligature-induced periodontitis in mouse.MethodsX · 2019Article
- Early intervention of peri-implantitis and periodontitis using a mouse model.Journal of periodontology · 2018Article
- Role of toll-like receptor 2 in inflammation and alveolar bone loss in experimental peri-implantitis versus periodontitis.Journal of periodontal research · 2018Article
- Susceptibility of different mouse strains to peri-implantitis.Journal of periodontal research · 2018Article
- Ligature-induced peri-implantitis and periodontitis in mice.Journal of clinical periodontology · 2018Article
- Enamel matrix derivative improves gingival fibroblast cell behavior cultured on titanium surfaces.Clinical oral investigations · 2016Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
BACKGROUND AND
objectivePeri-implantitis has a prevalence of 11-47%, involves destruction of peri-implant bone and may lead to implant loss. A detailed understanding of the pathogenesis of peri-implantitis is lacking. The objective of this study was to develop a murine model of experimental peri-implantitis. MATERIAL AND
methodsMachined, smooth-surface, screw-shaped titanium implants were placed in the healed alveolar bone of the left maxillary molars of C57BL/6J male mice, 8 wk after tooth extraction. Peri-implantitis was induced by securing silk ligatures around the head of the implant fixtures. Implant survival and peri-implant bone levels were analyzed by micro-computed tomography (micro-CT) scans and histology, 12 wk after ligature placement.
resultsImplant survival was 60% (six of 10) for implants with ligatures and 100% (eight of eight) for controls. Micro-CT revealed significantly greater bone loss around the implants that received ligatures and that survived, compared with controls. The radiographic findings were confirmed via histology and toluidine blue staining.
conclusionThis study describes a murine model of experimental peri-implantitis around screw-shaped titanium implants placed in the edentulous alveolar bone. This model should be a useful tool to dissect pathogenic mechanisms of peri-implantitis and evaluate potential treatment interventions.
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