ReviewNutrients2014
Does vitamin C deficiency affect cognitive development and function?
Review in Nutrients, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 100 citations in OpenAlex.
- Vitamin C Status and Cognitive Function: A Systematic Review.Nutrients · 2017Pooled it
- Diet and Neurodevelopmental Score in a Sample of One-Year-Old Children-A Cross-Sectional Study.Nutrients · 2019Trial
- Unraveling the Diet-Learning Nexus: a cross-sectional deep dive into Iranian adolescents' nutrient patterns and learning difficulties.BMC nutrition · 2026Article
- Plasma vitamin C levels are associated with brain structural networks on MRI: A large cohort study.PloS one · 2026Article
- Threshold Effects of Maternal Vitamin C in Late Pregnancy on Infant Social Competence: A Nonlinear Dose-Response Analysis in a Birth Cohort.Food science & nutrition · 2026Article
- Ascorbic acid attenuates immunosenescence and cognitive decline via MYH9-Mediated CD8⁺ T cell differentiation.Immunity & ageing : I & A · 2025Article
- Neuroprotective effects of vitamin C on hypoxic-ischemic brain injury in neonatal mice.Pediatric research · 2025Article
- Nutritional interventions to counteract the detrimental consequences of early-life stress.Molecular psychiatry · 2025Review
- Gene-dose effect of the glutathione biosynthesis gene on ascorbate deficiency in mice.Biochemical and biophysical research communications · 2025Article
- Vitamins in the Prevention and Support Therapy of Neurodegenerative Diseases.International journal of molecular sciences · 2025Review
- The protective role of prenatal administration of ascorbic acid on autistic-like behavior in a rat model of autism.IBRO neuroscience reports · 2024Article
- A Combinational Therapy for Preventing and Delaying the Onset of Alzheimer's Disease: A Focus on Probiotic and Vitamin Co-Supplementation.Antioxidants (Basel, Switzerland) · 2024Review
- The influence of multivitamins on neurological and growth disorders: a cross-sectional study.Frontiers in nutrition · 2024Article
- Diosgenin normalization of disrupted behavioral and central neurochemical activity after single prolonged stress.Frontiers in pharmacology · 2023Article
- The Role of Kiwifruit in Supporting Psychological Well-Being: A Rapid Review of the Literature.Nutrients · 2022Review
- Naturally Occurring Antioxidant Therapy in Alzheimer's Disease.Antioxidants (Basel, Switzerland) · 2022Review
- The Epigenetic Role of Vitamin C in Neurodevelopment.International journal of molecular sciences · 2022Review
- A Triple Combination of Targeting Ligands Increases the Penetration of Nanoparticles across a Blood-Brain Barrier Culture Model.Pharmaceutics · 2021Article
- Ascorbic acid detector based on fluorescent molybdenum disulfide quantum dots.Mikrochimica acta · 2021Article
- Beneficial Effects of Vitamin C in Maintaining Optimal Oral Health.Frontiers in nutrition · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vitamin C is a pivotal antioxidant in the brain and has been reported to have numerous functions, including reactive oxygen species scavenging, neuromodulation, and involvement in angiogenesis. Absence of vitamin C in the brain has been shown to be detrimental to survival in newborn SVCT2(-/-) mice and perinatal deficiency have shown to reduce hippocampal volume and neuron number and cause decreased spatial cognition in guinea pigs, suggesting that maternal vitamin C deficiency could have severe consequences for the offspring. Furthermore, vitamin C deficiency has been proposed to play a role in age-related cognitive decline and in stroke risk and severity. The present review discusses the available literature on effects of vitamin C deficiency on the developing and aging brain with particular focus on in vivo experimentation and clinical studies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.