Evidence map›Paper›PMID 25244106›Full record

ReviewImmunology2015

MicroRNAs affect dendritic cell function and phenotype.

Lesley A Smyth, Dominic A Boardman, Sim L Tung, Robert Lechler, Giovanna Lombardi

Open access · bronzeAbstract readReview
In one paragraph

Review in Immunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.

0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

73 citing papers in PubMed, 105 citations in OpenAlex.

  1. Trial
  2. Marine drugs · 2026
    Article
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  18. The Regulatory Effects of MicroRNAs on Tumor Immunity.BioMed research international · 2022
    Review
  19. Article
  20. hsa-MicroRNA-28-5p Inhibits Diffuse Large B-Cell Lymphoma Cell Proliferation by Downregulating 14-3-3Evidence-based complementary and alternative medicine : eCAM · 2022
    Article

13 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Lesley A SmythMRC Centre for Transplantation, King's College London, Guy's Hospital, London, UK.
Dominic A Boardman
Sim L Tung
Robert Lechler
Giovanna Lombardi
King's College London · GBGuy's Hospital · GB

Funding

British Heart Foundation RG/13/12/30395Medical Research Council MR/J006742/1
6 · The paper itself

Abstract

MicroRNA (miRNA) are small, non-coding RNA molecules that have been linked with immunity through regulating/modulating gene expression. A role for these molecules in T-cell and B-cell development and function has been well established. An increasing body of literature now highlights the importance of specific miRNA in dendritic cell (DC) development as well as their maturation process, antigen presentation capacity and cytokine release. Given the unique role of DC within the immune system, linking the innate and adaptive immune responses, understanding how specific miRNA affect DC function is of importance for understanding disease. In this review we summarize recent developments in miRNA and DC research, highlighting the requirement of miRNA in DC lineage commitment from bone marrow progenitors and for the development of subsets such as plasmacytoid DC and conventional DC. In addition, we discuss how infections and tumours modulate miRNA expression and consequently DC function.

Indexed as

AnimalsAntigen PresentationCell DifferentiationDendritic CellsGene Expression RegulationHematopoietic Stem CellsHumansImmune ToleranceMiceMicroRNAsPhenotypeVirus DiseasesMicroRNAsdendritic cellsimmune modulationmicroRNAs

Identifiers

PMID25244106
PMCPMC4298414
OpenAlexW1974136368

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.