ArticlePloS one2014
The effects of age and cytomegalovirus on markers of inflammation and lymphocyte populations in captive baboons.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 21 citations in OpenAlex.
- Sex-specific decline in prefrontal cortex mitochondrial bioenergetics in aging baboons correlates with walking speed.Neurobiology of aging · 2025Article
- Nonlinear Dynamics of TNFR1 and TNFR2 Expression on Immune Cells: Genetic and Age-Related Aspects of Inflamm-Aging Mechanisms.Biomedicines · 2025Article
- Sex-specific decline in prefrontal cortex mitochondrial bioenergetics in aging baboons correlates with walking speed.bioRxiv : the preprint server for biology · 2024Article
- Female baboon adrenal zona fasciculata and zona reticularis regulatory and functional proteins decrease across the life course.GeroScience · 2024Article
- Epidemiological characteristics and spatio-temporal aggregation of severe fever with thrombocytopenia syndrome in Jinan City, China, 2018-2022.PLoS neglected tropical diseases · 2023Article
- Article
- Immunosenescence and inflammaging in the aged horse.Immunity & ageing : I & A · 2023Review
- Are the Healthy Vulnerable? Cytomegalovirus Seropositivity in Healthy Adults Is Associated With Accelerated Epigenetic Age and Immune Dysregulation.The Journal of infectious diseases · 2022Article
- Effects of Chronic Viral Infection on Lymphocyte Populations in Middle-aged Baboons (Comparative medicine · 2021Article
- The nonhuman primate hypothalamo-pituitary-adrenal axis is an orchestrator of programming-aging interactions: role of nutrition.Nutrition reviews · 2020Review
- Impact of Cytomegalovirus Disease on New-Onset Type 2 Diabetes Mellitus: Population-Based Matched Case-Control Cohort Study.Diabetes & metabolism journal · 2019Article
- Characterization of Baboon Cytomegalovirus Infection in Healthy Adult Baboons (Comparative medicine · 2019Article
- CMV immune evasion and manipulation of the immune system with aging.GeroScience · 2017Article
- A decline in female baboon hypothalamo-pituitary-adrenal axis activity anticipates aging.Aging · 2017Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The human immune system undergoes age-related changes that can lead to increased disease susceptibility. Using the baboon as a model for human immune system aging, we examined age-related changes in relative and absolute numbers of T cell subpopulations, cytomegalovirus (CMV) titer and markers of inflammation. In addition, the effect of gender, social status and peer group on lymphocyte subpopulations was determined. Relative and absolute numbers of total lymphocytes (CD3+), T helper cells (CD4+), and cytotoxic T cells (CD8+) increased with age. The proportion of naïve T cells (CD45RA+) decreased, while the total number of cells negative for the co-stimulatory receptor, CD28 (CD28-) increased in an age-dependent manner. Furthermore, CMV titers were negatively correlated with the number of naive CD4+ cells. IL-6 and cortisol concentration were also negatively associated with T cell subpopulations. Additionally, socially dominant baboons exhibited decreases in naïve CD4+ and CD8+ cells (by 65% and 52%, respectively) compared to subordinate animals. These results suggest that factors such as CMV exposure and inflammation may contribute to the age-related decline in immune health and indicate that factors like social status should be considered when studying immunosenescence in animal models.
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Registered trials
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