ArticleInternational journal of molecular sciences2014
Inhibitory effects of adlay extract on melanin production and cellular oxygen stress in B16F10 melanoma cells.
Article in International journal of molecular sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 44 citations in OpenAlex.
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- The neuroprotective effect of traditional Chinese medicinal plants-A critical review.Acta pharmaceutica Sinica. B · 2023Review
- Article
- The Modulation of Melanogenesis in B16 Cells Upon Treatment with Plant Extracts and Isolated Plant Compounds.Molecules (Basel, Switzerland) · 2022Review
- Effects of novel cellulase (Cel 906) and probiotic yeast fermentation on antioxidant and anti-inflammatory activities of vine tea (Frontiers in bioengineering and biotechnology · 2022Article
- Characterization of Phenethyl Cinnamamide Compounds from Hemp Seed and Determination of Their Melanogenesis Inhibitory Activity.ACS omega · 2021Article
- Anti-Melanogenic Properties of Velutin and Its Analogs.Molecules (Basel, Switzerland) · 2021Article
- Identification of Sitogluside as a Potential Skin-Pigmentation-Reducing Agent through Network Pharmacology.Oxidative medicine and cellular longevity · 2021Article
- Ethnobotanical Survey on Skin Whitening Prescriptions of Traditional Chinese Medicine in Taiwan.Frontiers in pharmacology · 2021Article
- Characterization of Caffeoylquinic Acids fromACS omega · 2020Article
- Nanoemulsified adlay bran oil reduces tyrosinase activity and melanin synthesis in B16F10 cells and zebrafish.Food science & nutrition · 2019Article
- Anti-Melanogenic Effect from Submerged Mycelial Cultures ofMycobiology · 2019Article
- The effect of a coix seed oil injection on cancer pain relief.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2019Article
- Identification of Anti-Melanogenesis Constituents fromMolecules (Basel, Switzerland) · 2018Article
- Selected Enzyme Inhibitory Effects ofBioMed research international · 2018Article
- Inhibitory effects of Stichopus japonicus extract on melanogenesis of mouse cells via ERK phosphorylation.Molecular medicine reports · 2017Article
- Inhibitory effects of different fractions ofResearch in pharmaceutical sciences · 2017Article
- Effects of protein hydrolysate from chicken feather meal on tyrosinase activity and melanin formation in B16F10 murine melanoma cells.Food science and biotechnology · 2017Article
- Inhibitory Effect of Dried Pomegranate Concentration Powder on Melanogenesis in B16F10 Melanoma Cells; Involvement of p38 and PKA Signaling Pathways.International journal of molecular sciences · 2015Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to determine the effects of adlay extract on melanin production and the antioxidant characteristics of the extract. The seeds were extracted by the supercritical fluid CO2 extraction (SFE) method. The effect of adlay extract on melanin production was evaluated using mushroom tyrosinase activity assay, intracellular tyrosinase activity, antioxidant properties and melanin content. Those assays were performed spectrophotometrically. In addition, the expression of melanogenesis-related proteins was determined by western blotting. The results revealed that the adlay extract suppressed intracellular tyrosinase activity and decreased the amount of melanin in B16F10 cells. The adlay extract decreased the expression of microphthalmia-associated transcription factor (MITF), tyrosinase, tyrosinase related protein-1 (TRP-1) and tyrosinase related protein-2 (TRP-2). The extract also exhibited antioxidant characteristics such as free radical scavenging capacity and reducing power. It effectively decreased intracellular reactive oxygen species (ROS) levels in B16F10 cells. We concluded that the adlay extract inhibits melanin production by down-regulation of MITF, tyrosinase, TRP-1 and TRP-2. The antioxidant properties of the extract may also contribute to the inhibition of melanogenesis. The adlay extract can therefore be applied as an inhibitor of melanogenesis and could also act as a natural antioxidant in skin care products.
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