ArticleThe EMBO journal1989
Regulation of tissue-specific alternative splicing: exon-specific cis-elements govern the splicing of leukocyte common antigen pre-mRNA.
Article in The EMBO journal, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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Who cites it
55 citing papers in PubMed, 152 citations in OpenAlex.
- RNA-based diagnostic studies in genetics: Review and guidance from a multidisciplinary French network.European journal of human genetics : EJHG · 2025Review
- Genome annotation with long RNA reads reveals new patterns of gene expression and improves single-cell analyses in an ant brain.BMC biology · 2021Article
- The mechanisms of a mammalian splicing enhancer.Nucleic acids research · 2018Article
- Article
- Characterization of mammalian Par 6 as a dual-location protein.Molecular and cellular biology · 2007Article
- Article
- Splicing enhancement in the yeast rp51b intron.RNA (New York, N.Y.) · 2000Article
- A model system for activation-induced alternative splicing of CD45 pre-mRNA in T cells implicates protein kinase C and Ras.Molecular and cellular biology · 2000Article
- The SR splicing factors ASF/SF2 and SC35 have antagonistic effects on intronic enhancer-dependent splicing of the beta-tropomyosin alternative exon 6A.The EMBO journal · 1997Article
- Smooth muscle alternative splicing induced in fibroblasts by heterologous expression of a regulatory gene.The EMBO journal · 1996Article
- Trans-acting factors regulate the expression of CD44 splice variants.The EMBO journal · 1996Article
- Selection of novel exon recognition elements from a pool of random sequences.Molecular and cellular biology · 1995Article
- A 32-nucleotide exon-splicing enhancer regulates usage of competing 5' splice sites in a differential internal exon.Molecular and cellular biology · 1995Article
- Cloning and expression of protein tyrosine phosphatase-like protein derived from a rat pheochromocytoma cell line.The Biochemical journal · 1995Article
- SR proteins promote the first specific recognition of Pre-mRNA and are present together with the U1 small nuclear ribonucleoprotein particle in a general splicing enhancer complex.Molecular and cellular biology · 1994Article
- Nonsense but not missense mutations can decrease the abundance of nuclear mRNA for the mouse major urinary protein, while both types of mutations can facilitate exon skipping.Molecular and cellular biology · 1994Article
- Interleukin 2 receptor gamma chain expression on resting and activated lymphoid cells.The Journal of experimental medicine · 1994Article
- Alternative splicing of beta-tropomyosin pre-mRNA: multiple cis-elements can contribute to the use of the 5'- and 3'-splice sites of the nonmuscle/smooth muscle exon 6.Nucleic acids research · 1994Article
- Enhancement of antigen-induced T-cell proliferation by soluble CD26/dipeptidyl peptidase IV.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- A novel bipartite splicing enhancer modulates the differential processing of the human fibronectin EDA exon.Nucleic acids research · 1994Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Tissue-specific alternative splicing is an important mechanism for controlling gene expression. Exons 4, 5 and 6 of the human leukocyte common antigen (LCA) gene are included in B cell mRNA but excluded from thymocyte mRNA by differential splicing. In order to study this tissue-specific alternative splicing, we constructed mini-genes that contain only a few of the LCA exons and the SV40 promoter. Mouse B cells and thymocytes were transfected with these mini-gene constructs and the structures of mRNAs were determined by primer extension analysis. The results show that the same primary transcript is spliced alternatively in B cells and thymocytes. This finding suggests that there is a tissue-specific trans-acting factor that regulates the alternative splicing of LCA pre-mRNA. By making various deletion mutants, cis-elements necessary for tissue-specific splicing were confined within the alternatively spliced exons and their immediate flanking intron sequences. Furthermore, linker scanning analysis shows that there are at least three distinct cis-elements within the LCA exon 4 sequence that are required for tissue-specific alternative splicing. Possible mechanisms of LCA alternative splicing are discussed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.