ArticleThe Journal of investigative dermatology2015
Genetic variants in fanconi anemia pathway genes BRCA2 and FANCA predict melanoma survival.
Article in The Journal of investigative dermatology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 37 citations in OpenAlex.
- Hematological Toxicities in the Modern Era of Melanoma Therapy.Journal of clinical medicine · 2026Review
- Predicting depression risk in middle-aged and elderly adults in China using CNN-BiLSTM-Attention mechanism and LSTM+SHAP framework.BMC psychiatry · 2025Article
- Inequalities in Mild Cognitive Impairment Risk Among Chinese Middle-Aged and Older Adults: Insights from an Integrated Learning Model.Risk management and healthcare policy · 2025Article
- Exploring the Common Mutational Landscape in Cutaneous Melanoma and Pancreatic Cancer.Pigment cell & melanoma research · 2025Review
- Transcriptome-Wide Association Study Reveals New Molecular Interactions Associated with Melanoma Pathogenesis.Cancers · 2024Article
- Gastric cancer with Fanconi anemia in adolescent and young adult patient diagnosed by comprehensive genome profiling using next-generation sequencing.Clinical journal of gastroenterology · 2024Article
- Gene-Environment Analyses in a UK Biobank Skin Cancer Cohort Identifies Important SNPs in DNA Repair Genes That May Help Prognosticate Disease Risk.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2023Article
- Article
- FANCA Polymorphism Is Associated with the Rate of Proliferation in Uterine Leiomyoma in Korea.Journal of personalized medicine · 2020Article
- Novel Genetic Variants ofCancers · 2020Article
- Integrated case-control and somatic-germline interaction analyses of melanoma susceptibility genes.Biochimica et biophysica acta. Molecular basis of disease · 2018Article
- Genome-wide association study in 176,678 Europeans reveals genetic loci for tanning response to sun exposure.Nature communications · 2018Article
- BRCA1/2 mutations are not a common cause of malignant melanoma in the Polish population.PloS one · 2018Article
- Impact of phosphoinositide-3-kinase and vitamin D3 nuclear receptor single-nucleotide polymorphisms on the outcome of malignant melanoma patients.Oncotarget · 2017Article
- Genetic variants in the genes encoding rho GTPases and related regulators predict cutaneous melanoma-specific survival.International journal of cancer · 2017Article
- Genetic variants in the integrin signaling pathway genes predict cutaneous melanoma survival.International journal of cancer · 2017Article
- Genetic variants in the PIWI-piRNA pathway gene DCP1A predict melanoma disease-specific survival.International journal of cancer · 2016Article
- Inherited functional variants of the lymphocyte receptor CD5 influence melanoma survival.International journal of cancer · 2016Article
- Genetic variants in the vitamin D pathway genes VDBP and RXRA modulate cutaneous melanoma disease-specific survival.Pigment cell & melanoma research · 2016Article
- Vitamin D receptor polymorphisms and survival in patients with cutaneous melanoma: a population-based study.Carcinogenesis · 2016Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
Cutaneous melanoma (CM) is the most lethal skin cancer. The Fanconi anemia (FA) pathway involved in DNA crosslink repair may affect CM susceptibility and prognosis. Using data derived from published genome-wide association study, we comprehensively analyzed the associations of 2,339 common single-nucleotide polymorphisms (SNPs) in 14 autosomal FA genes with overall survival (OS) in 858 CM patients. By performing false-positive report probability corrections and stepwise Cox proportional hazards regression analyses, we identified significant associations between CM OS and four putatively functional SNPs: BRCA2 rs10492396 (AG vs. GG: adjusted hazard ratio (adjHR)=1.85, 95% confidence interval (CI)=1.16-2.95, P=0.010), rs206118 (CC vs. TT+TC: adjHR=2.44, 95% CI=1.27-4.67, P=0.007), rs3752447 (CC vs. TT+TC: adjHR=2.10, 95% CI=1.38-3.18, P=0.0005), and FANCA rs62068372 (TT vs. CC+CT: adjHR=1.85, 95% CI=1.27-2.69, P=0.001). Moreover, patients with an increasing number of unfavorable genotypes (NUG) of these loci had markedly reduced OS and melanoma-specific survival (MSS). The final model incorporating with NUG, tumor stage, and Breslow thickness showed an improved discriminatory ability to classify both 5-year OS and 5-year MSS. Additional investigations, preferably prospective studies, are needed to validate our findings.
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