ArticleThe Journal of clinical endocrinology and metabolism2014
Body composition during childhood and adolescence: relations to bone strength and microstructure.
Article in The Journal of clinical endocrinology and metabolism, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 53 citations in OpenAlex.
- Skeletal Effects of Nine Months of Physical Activity in Obese and Healthy Weight Children.Medicine and science in sports and exercise · 2020Trial
- Soft tissues, areal bone mineral density and hip geometry estimates in active young boys: the PRO-BONE study.European journal of applied physiology · 2017Trial
- Opportunistic assessment of bone mineral density using computed tomography in pediatric liver transplant recipients.European journal of pediatrics · 2026Article
- Impaired bone health after pediatric acute lymphoblastic leukemia treatment despite normal DXA: insights from high-resolution peripheral quantitative computed tomography.Frontiers in endocrinology · 2026Article
- Insufficient Bone Mineralization to Sustain Mechanical Load of Weight in Obese Boys: A Cross-Sectional Study.The Journal of clinical endocrinology and metabolism · 2024Article
- Epidemiological Investigation of Pediatric Fractures-A Retrospective Cohort Study of 1129 Patients.Medicina (Kaunas, Lithuania) · 2023Article
- Handgrip strength assessment at baseline in addition to bone parameters could potentially predict the risk of curve progression in adolescent idiopathic scoliosis.Frontiers in pediatrics · 2023Article
- Article
- Factors influencing peak bone mass gain.Frontiers of medicine · 2021Review
- Associations of Weight-Adjusted Body Fat and Fat Distribution with Bone Mineral Density in Chinese Children Aged 6-10 Years.International journal of environmental research and public health · 2020Article
- The Bones of Children With Obesity.Frontiers in endocrinology · 2020Review
- A Perspective on Management of Limb Fractures in Obese Children: Is It Time for Dedicated Guidelines?Frontiers in pediatrics · 2020Article
- Association of body composition with predicted hip bone strength among Chinese postmenopausal women: a longitudinal study.Scientific reports · 2019Article
- The Impact of Childhood Obesity on Skeletal Health and Development.Journal of obesity & metabolic syndrome · 2019Review
- Estimating body mass and composition from proximal femur dimensions using dual energy x-ray absorptiometry.Archaeological and anthropological sciences · 2019Article
- The role of PPARγ in childhood obesity-induced fractures.Genes & nutrition · 2019Review
- Article
- Article
- Fat and bone in children - where are we now?Annals of pediatric endocrinology & metabolism · 2018Article
- Differential Adaptive Response of Growing Bones From Two Female Inbred Mouse Strains to Voluntary Cage-Wheel Running.JBMR plus · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
contextNumerous studies have examined the association of body composition with bone development in children and adolescents, but none have used micro-finite element (μFE) analysis of high-resolution peripheral quantitative computed tomography images to assess bone strength.
objectiveThis study sought to examine the relations of appendicular lean mass (ALM) and total body fat mass (TBFM) to bone strength (failure load) at the distal radius and tibia. DESIGN, PARTICIPANTS, AND
settingThis was a cross-sectional study of 198 healthy 8- to <15-year-old boys (n = 109) and girls (n = 89) performed in a Clinical Research Unit.
resultsAfter adjusting for bone age, height, fracture history, ALM, and TBFM, multiple linear regression analyses in boys and girls, separately, showed robust positive associations between ALM and failure loads at both the distal radius (boys: β = 0.92, P < .001; girls: β = 0.66, P = .001) and tibia (boys: β = 0.96, P < .001; girls: β = 0.66, P < .001). By contrast, in both boys and girls the relationship between TBFM and failure load at the distal radius was virtually nonexistent (boys: β = -0.07; P = .284; girls: β = -0.03; P = .729). At the distal tibia, positive, albeit weak, associations were observed between TBFM and failure load in both boys (β = 0.09, P = .075) and girls (β = 0.17, P = .033).
conclusionsOur data highlight the importance of lean mass for optimizing bone strength during growth, and suggest that fat mass may have differential relations to bone strength at weight-bearing vs non-weight-bearing sites in children and adolescents. These observations suggest that the strength of the distal radius does not commensurately increase with excess gains in adiposity during growth, which may result in a mismatch between bone strength and the load experienced by the distal forearm during a fall. These findings may explain, in part, why obese children are over-represented among distal forearm fracture cases.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.