ArticleBipolar disorders2014
Correlation between DNA methylation and gene expression in the brains of patients with bipolar disorder and schizophrenia.
Article in Bipolar disorders, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 3 of them syntheses that pooled it.
What it found
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Who cites it
57 citing papers in PubMed, 3 syntheses or guidelines pooled it, 110 citations in OpenAlex.
- A perspective on epigenomic aging processes in the human brain and their plasticity in patients with mental disorders - a systematic review.Neurogenetics · 2024Pooled it
- Dissecting the shared genetic landscape of anxiety, depression, and schizophrenia.Journal of translational medicine · 2024Pooled it
- Epigenetic mechanisms in schizophrenia and other psychotic disorders: a systematic review of empirical human findings.Molecular psychiatry · 2020Pooled it
- Multi-omics integration uncovers epigenetic control of metabolic reprogramming in triple-negative breast cancer.Journal of the Egyptian National Cancer Institute · 2026Article
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- Premature aging in serious mental illness.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Shared Genetic Architecture Between Endometriosis and Psychiatric Conditions May Explain Comorbidity.medRxiv : the preprint server for health sciences · 2025Article
- Artificial intelligence-driven multi-omics approaches in Alzheimer's disease: Progress, challenges, and future directions.Acta pharmaceutica Sinica. B · 2025Review
- MethAgingDB: a comprehensive DNA methylation database for aging biology.Scientific data · 2025Article
- Epigenetic Control in Schizophrenia.Sub-cellular biochemistry · 2025Review
- Identification of DNA methylation markers for age and Bovine Respiratory Disease in dairy cattle: A pilot study based on Reduced Representation Bisulfite Sequencing.Communications biology · 2024Article
- Cortico-striatal differences in the epigenome in attention-deficit/ hyperactivity disorder.Translational psychiatry · 2024Article
- Alpha-synuclein overexpression induces epigenomic dysregulation of glutamate signaling and locomotor pathways.Human molecular genetics · 2022Article
- Spatiotemporal specificity of correlated DNA methylation and gene expression pairs across different human tissues and stages of brain development.Epigenetics · 2022Article
- Effect of Prenatal Opioid Exposure on the Human Placental Methylome.Biomedicines · 2022Article
- Epigenome-wide association study of alcohol use disorder in five brain regions.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Integrated co-expression network analysis uncovers novel tissue-specific genes in major depressive disorder and bipolar disorder.Frontiers in psychiatry · 2022Article
- Subtypes of schizophrenia identified by multi-omic measures associated with dysregulated immune function.Molecular psychiatry · 2021Article
- Review
- DNA methylome perturbations: an epigenetic basis for the emergingly heritable neurodevelopmental abnormalities associated with maternal smoking and maternal nicotine exposure†.Biology of reproduction · 2021Review
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
Abstract
objectivesAberrant DNA methylation and gene expression have been reported in postmortem brain tissues of psychotic patients, but until now there has been no systematic evaluation of synergistic changes in methylation and expression on a genome-wide scale in brain tissue.
methodsIn this study, genome-wide methylation and expression analyses were performed on cerebellum samples from 39 patients with schizophrenia, 36 patients with bipolar disorder, and 43 unaffected controls, to screen for a correlation between gene expression and CpG methylation.
resultsOut of 71,753 CpG gene pairs (CGPs) tested across the genome, 204 were found to significantly correlate with gene expression after correction for multiple testing [p < 0.05, false discovery rate (FDR) q < 0.05]. The correlated CGPs were tested for disease-associated expression and methylation by comparing psychotic patients with bipolar disorder and schizophrenia to healthy controls. Four of the identified CGPs were found to significantly correlate with the differential expression and methylation of genes encoding phosphoinositide-3-kinase, regulatory subunit 1 (PIK3R1), butyrophilin, subfamily 3, member A3 (BTN3A3), nescient helix-loop-helix 1 (NHLH1), and solute carrier family 16, member 7 (SLC16A7) in psychotic patients (p < 0.05, FDR q < 0.2). Additional expression and methylation datasets were used to validate the relationship between DNA methylation, gene expression, and neuropsychiatric diseases.
conclusionsThese results suggest that the identified differentially expressed genes with an aberrant methylation pattern may represent novel candidate factors in the etiology and pathology of neuropsychiatric disorders.
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