ArticleMolecular ecology2014
Environmental systems biology of cold-tolerant phenotype in Saccharomyces species adapted to grow at different temperatures.
Article in Molecular ecology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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37 citing papers in PubMed, 81 citations in OpenAlex.
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- The evolution of thermal performance curves in response to rising temperatures across the model genus yeast.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Exploring adaptation routes to cold temperatures in the Saccharomyces genus.PLoS genetics · 2025Article
- Investigation of cold-resistance mechanisms in cryophylactic yeastFrontiers in microbiology · 2024Article
- A Dynamic Genome-Scale Model Identifies Metabolic Pathways Associated with Cold Tolerance in Saccharomyces kudriavzevii.Microbiology spectrum · 2023Article
- The impact of selected abiotic factors on Artemia hatching process through real-time observation of oxygen changes in a microfluidic platform.Scientific reports · 2023Article
- Exploring Thermal Sensitivities and Adaptations of Oxidative Phosphorylation Pathways.Metabolites · 2022Review
- Deciphering the mechanism by which the yeast Phaffia rhodozyma responds adaptively to environmental, nutritional, and genetic cues.Journal of industrial microbiology & biotechnology · 2021Review
- Transcriptional Profile of the Industrial Hybrid Saccharomyces pastorianus Reveals Temperature-Dependent Allele Expression Bias and Preferential Orthologous Protein Assemblies.Molecular biology and evolution · 2021Article
- Restoring fertility in yeast hybrids: Breeding and quantitative genetics of beneficial traits.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Characterization of Cold-TolerantMicroorganisms · 2021Article
- Yeast Fermentation at Low Temperatures: Adaptation to Changing Environmental Conditions and Formation of Volatile Compounds.Molecules (Basel, Switzerland) · 2021Review
- Industrially ApplicableApplied and environmental microbiology · 2021Article
- Differential proteomic analysis by SWATH-MS unravels the most dominant mechanisms underlying yeast adaptation to non-optimal temperatures under anaerobic conditions.Scientific reports · 2020Article
- First De Novo Transcriptome of the CopepodBiology · 2020Article
- An update on the diversity, ecology and biogeography of the Saccharomyces genus.FEMS yeast research · 2020Review
- Genomic Adaptation ofFrontiers in genetics · 2020Review
- Comparative transcriptional analysis of flavour-biosynthetic genes of a nativeJournal of biological research (Thessalonike, Greece) · 2019Article
- Temperature preference can bias parental genome retention during hybrid evolution.PLoS genetics · 2019Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Temperature is one of the leading factors that drive adaptation of organisms and ecosystems. Remarkably, many closely related species share the same habitat because of their different temporal or micro-spatial thermal adaptation. In this study, we seek to find the underlying molecular mechanisms of the cold-tolerant phenotype of closely related yeast species adapted to grow at different temperatures, namely S. kudriavzevii CA111 (cryo-tolerant) and S. cerevisiae 96.2 (thermo-tolerant). Using two different systems approaches, i. thermodynamic-based analysis of a genome-scale metabolic model of S. cerevisiae and ii. large-scale competition experiment of the yeast heterozygote mutant collection, genes and pathways important for the growth at low temperature were identified. In particular, defects in lipid metabolism, oxidoreductase and vitamin pathways affected yeast fitness at cold. Combining the data from both studies, a list of candidate genes was generated and mutants for two predicted cold-favouring genes, GUT2 and ADH3, were created in two natural isolates. Compared with the parental strains, these mutants showed lower fitness at cold temperatures, with S. kudriavzevii displaying the strongest defect. Strikingly, in S. kudriavzevii, these mutations also significantly improve the growth at warm temperatures. In addition, overexpression of ADH3 in S. cerevisiae increased its fitness at cold. These results suggest that temperature-induced redox imbalances could be compensated by increased glycerol accumulation or production of cytosolic acetaldehyde through the deletion of GUT2 or ADH3, respectively.
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