ArticleBioMed research international2014
Aluminium involvement in neurotoxicity.
Article in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.
- MicroRNAs as potential signatures of environmental exposure or effect: a systematic review.Environmental health perspectives · 2015Pooled it
- Evaluation of L-carnitine's protective properties against AlCl3-induced brain, liver, and renal toxicity in rats.PloS one · 2025Article
- Aluminium in the Human Brain: Routes of Penetration, Toxicity, and Resulting Complications.International journal of molecular sciences · 2023Review
- A Mini Review of Antibacterial Properties of AlNanomaterials (Basel, Switzerland) · 2022Review
- Antiamnesic Potential of Malvidin on Aluminum Chloride Activated by the Free Radical Scavenging Property.ACS omega · 2022Article
- Aluminum Poisoning with Emphasis on Its Mechanism and Treatment of Intoxication.Emergency medicine international · 2022Review
- Air pollution and multiple sclerosis: a comprehensive review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Review
- Aluminium release and fluid warming: provocational setting and devices at risk.BMC anesthesiology · 2021Article
- Biochemical, histological, and neuro-physiological effects of long-term aluminum chloride exposure in rats.Metabolic brain disease · 2021Article
- Influence of aluminum salts on COVID-19 infected patientsTurkish journal of medical sciences · 2020Observational
- Apoptotic Inducement of Neuronal Cells by Aluminium Chloride and the Neuroprotective Effect of Eugenol in Wistar Rats.Oxidative medicine and cellular longevity · 2020Article
- EDTA Chelation Therapy for the Treatment of Neurotoxicity.International journal of molecular sciences · 2019Review
- The putative role of environmental aluminium in the development of chronic neuropathology in adults and children. How strong is the evidence and what could be the mechanisms involved?Metabolic brain disease · 2017Review
- Rationale for the Successful Management of EDTA Chelation Therapy in Human Burden by Toxic Metals.BioMed research international · 2016Review
- The protective properties of melatonin against aluminium-induced neuronal injury.International journal of experimental pathology · 2015Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aetiology of neurodegenerative diseases (ND) seems to involve susceptibility genes and environmental factors. Toxic metals are considered major environmental pollutants. Following our study of a case of multiple sclerosis (MS) improvement due to removal of aluminium (Al) and other toxic metals, we have examined the possible relationship between Al intoxication and ND. We used the slow intravenous treatment with the chelating agent EDTA (calcium disodium ethylene diamine tetraacetic acid) (chelation test) to remove Al and detected it in the urine collected from the patients for 12 hours. Patients affected by MS represented 85.6% of total ND. Al was present in 44.8% of cases comprehensive of ND and healthy patients. Al levels were significantly higher in ND patients than in healthy subjects. We here show that treatment of patients affected by Al burden with ten EDTA chelation therapies (EDTA intravenous administration once a week) was able to significantly reduce Al intoxication.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.