Evidence map›Paper›PMID 25243161›Full record

ArticleBioMed research international2014

Impact of blood type, functional polymorphism (T-1676C) of the COX-1 gene promoter and clinical factors on the development of peptic ulcer during cardiovascular prophylaxis with low-dose aspirin.

Pin-Yao Wang, Hsiu-Ping Chen, Angela Chen, Feng-Woei Tsay, Kwok-Hung Lai, Sung-Shuo Kao, Wen-Chi Chen, Chao-Hung Kuo, Nan-Jing Peng, Hui-Hwa Tseng and 1 more

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In one paragraph

Article in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Pin-Yao WangInstitute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung 804, Taiwan.
Hsiu-Ping ChenInstitute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung 804, Taiwan.
Angela ChenInstitute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung 804, Taiwan.
Feng-Woei TsayDivision of Gastroenterology, Department of Internal Medicine, Kaohsiung Veterans General Hospital, 386 Ta Chung 1st Road, Kaohsiung 813, Taiwan ; School of Medicine, National Yang-Ming University, Taipei 112, Taiwan.
Kwok-Hung LaiDivision of Gastroenterology, Department of Internal Medicine, Kaohsiung Veterans General Hospital, 386 Ta Chung 1st Road, Kaohsiung 813, Taiwan ; School of Medicine, National Yang-Ming University, Taipei 112, Taiwan.ORCID 0000-0002-3085-6534
Sung-Shuo KaoDivision of Gastroenterology, Department of Internal Medicine, Kaohsiung Veterans General Hospital, 386 Ta Chung 1st Road, Kaohsiung 813, Taiwan ; School of Medicine, National Yang-Ming University, Taipei 112, Taiwan.
Wen-Chi ChenDivision of Gastroenterology, Department of Internal Medicine, Kaohsiung Veterans General Hospital, 386 Ta Chung 1st Road, Kaohsiung 813, Taiwan ; School of Medicine, National Yang-Ming University, Taipei 112, Taiwan ; Department of Chemistry, College of Science, National Kaohsiung Normal University, Kaohsiung 802, Taiwan.ORCID 0000-0002-7572-4201
Chao-Hung KuoDivision of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan.ORCID 0000-0002-6027-8296
Nan-Jing PengSchool of Medicine, National Yang-Ming University, Taipei 112, Taiwan ; Department of Nuclear Medicine, Kaohsiung Veterans General Hospital and National Yang-Ming University, Kaohsiung 813, Taiwan.
Hui-Hwa TsengDepartment of Pathology, Kaohsiung Veterans General Hospital, Kaohsiung 813, Taiwan.
Ping-I HsuDivision of Gastroenterology, Department of Internal Medicine, Kaohsiung Veterans General Hospital, 386 Ta Chung 1st Road, Kaohsiung 813, Taiwan ; School of Medicine, National Yang-Ming University, Taipei 112, Taiwan.
National Yang Ming Chiao Tung University · TWNational Sun Yat-sen University · TWKaohsiung Medical University · TWKaohsiung Veterans General Hospital · TWNational Kaohsiung Normal University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsTo investigate the impact of blood type, functional polymorphism (T-1676C) of the COX-1 gene promoter, and clinical factors on the development of peptic ulcer during cardiovascular prophylaxis with low-dose aspirin.

methodsIn a case-control study including 111 low-dose aspirin users with peptic ulcers and 109 controls (asymptomatic aspirin users), the polymorphism (T-1676C) of the COX-1 gene promoter was genotyped, and blood type, H pylori status, and clinical factors were assessed.

resultsUnivariate analysis showed no significant differences in genotype frequencies of the COX-1 gene at position -1676 between the peptic ulcer group and control group. Multivariate analysis revealed that blood type O, advanced age, history of peptic ulcer, and concomitant use of NSAID were the independent risk factors for the development of peptic ulcer with the odds ratios of the 2.1, 3.1, 27.6, and 2.9, respectively.

conclusionThe C-1676T polymorphism in the COX-1 gene promoter is not a risk factor for ulcer formation during treatment with low-dose aspirin. Blood type O, advanced age, history of peptic ulcer, and concomitant use of NSAID are of independent significance in predicting peptic ulcer development during treatment with low-dose aspirin.

Indexed as

ABO Blood-Group SystemAgedAged, 80 and overAspirinCardiovascular DiseasesCase-Control StudiesCyclooxygenase 1FemaleGenotypeHumansMaleMiddle AgedPeptic UlcerPolymorphism, GeneticPromoter Regions, GeneticRisk FactorsABO Blood-Group SystemAspirinCyclooxygenase 1PTGS1 protein, human

Identifiers

PMID25243161
PMCPMC4163467
OpenAlexW2121644340

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.