ReviewGastroenterology research and practice2014
Pharmacologic prophylaxis of portal venous system thrombosis after splenectomy: a meta-analysis.
Review in Gastroenterology research and practice, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 4 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 4 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Long term prophylactic anticoagulation for portal vein thrombosis after splenectomy: A systematic review and meta-analysis.PloS one · 2023Pooled it
- Splanchnic Vein Thrombosis in Liver Cirrhosis After Splenectomy or Splenic Artery Embolization: A Systematic Review and Meta-Analysis.Advances in therapy · 2021Pooled it
- Low-molecular weight heparin prevents portal vein system thrombosis after splenectomy: a systematic review and meta-analysis.ANZ journal of surgery · 2020Pooled it
- Nonselective beta-blockers and development of portal vein thrombosis in liver cirrhosis: a systematic review and meta-analysis.Hepatology international · 2019Pooled it
- Machine learning predicts portal vein thrombosis after splenectomy in patients with portal hypertension: Comparative analysis of three practical models.World journal of gastroenterology · 2022Trial
- Successful management of postpartum venous thrombosis following splenectomy for traumatic splenic rupture: a case report.The Journal of international medical research · 2024Article
- Early prevention and risk factors analysis of portal vein system thrombosis after laparoscopic splenectomy and pericardial devascularization.Surgical endoscopy · 2022Article
- Association of endoscopic variceal treatment with portal venous system thrombosis in liver cirrhosis: a case-control study.Therapeutic advances in gastroenterology · 2022Article
- Splenic volume and splenic vein diameter are independent pre-operative risk factors of portal vein thrombosis after splenectomy: a retrospective cohort study.BMC surgery · 2021Article
- 'Wandering spleen with acute torsion' : a rare indication for splenectomy in an adult, complicated by postoperative splanchnic venous thrombosis and intestinal gangrene.BMJ case reports · 2021Article
- Splenectomy for benign and malignant hematologic pathology: Modern morbidity, mortality, and long-term outcomes.Surgery open science · 2020Article
- Position of the Pancreas Division Line and Postoperative Outcomes After Distal Pancreatectomy.World journal of surgery · 2020Article
- Risk Factors of Portal Vein Thrombosis after Devascularization Treatment in Patients with Liver Cirrhosis: A Nested Case-Control Study.BioMed research international · 2020Article
- Effects of early antiplatelet therapy after splenectomy with gastro-oesophageal devascularization.ANZ journal of surgery · 2018Article
- Association Between Changes in Splanchnic Hemodynamics and Risk Factors of Portal Venous System Thrombosis After Splenectomy with Periesophagogastric Devascularization.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- The Best Anticoagulation Strategy for Cirrhotic Patients who Underwent Splenectomy: A Network Meta-Analysis.Gastroenterology research and practice · 2017Review
- Early prophylactic anticoagulation for portal vein system thrombosis after splenectomy: A systematic review and meta-analysis.Biomedical reports · 2016Article
- Splenectomy Causes 10-Fold Increased Risk of Portal Venous System Thrombosis in Liver Cirrhosis Patients.Medical science monitor : international medical journal of experimental and clinical research · 2016Article
- Association between D-dimer level and portal venous system thrombosis in liver cirrhosis: a retrospective observational study.International journal of clinical and experimental medicine · 2015Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Portal venous system thrombosis (PVST) is a life-threatening complication of splenectomy. A meta-analysis was conducted to explore the role of pharmacologic prophylaxis of PVST after splenectomy. Overall, 359 papers were initially identified via the PubMed, EMBASE, and Cochrane Library databases. Eight of them were eligible. The incidence of PVST after splenectomy was significantly lower in patients who received the preventive measures than in those who did not (odds ratio [OR]: 0.33, 95% confidence interval [CI]: 0.22-0.47, P < 0.00001). Subgroup analyses demonstrated that the significant difference remained in studies including patients with portal hypertension (n = 6), but not in those including patients with hematological diseases (n = 2); the significant difference remained in studies using any type of prophylactic drugs (anticoagulants [n = 6], thrombolytics [n = 1], and prostaglandin E1 [n = 1]); the significant difference remained in nonrandomized studies (n = 5), but not in randomized studies (n = 3). The risk of bleeding was similar between the two groups (OR: 0.65, 95% CI: 0.10-4.04, P = 0.64). In conclusion, pharmacologic prophylaxis might decrease the incidence of PVST after splenectomy in patients with portal hypertension and did not increase the risk of bleeding. However, the effect of pharmacologic prophylaxis of PVST in patients with hematological diseases remained questioned.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.