ArticleIranian journal of reproductive medicine2012
No association of GSTM1 null polymorphism with endometriosis in women from central and southern Iran.
Article in Iranian journal of reproductive medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 9 citations in OpenAlex.
- Defining the genetic profile of endometriosis.Experimental and therapeutic medicine · 2019Review
- Relationship betweenInternational journal of reproductive biomedicine · 2018Article
- Association between glutathione S-transferase M1/T1 gene polymorphisms and susceptibility to endometriosis: A systematic review and meta-analysis.Experimental and therapeutic medicine · 2016Article
- Association study of Glutathione S-Transferase polymorphisms and risk of endometriosis in an Iranian population.International journal of reproductive biomedicine · 2016Article
- Investigating GSTT1 and GSTM1 null genotype as the risk factor of diabetes type 2 retinopathy.Journal of diabetes and metabolic disorders · 2013Article
- Association of TP53 gene codon 72 polymorphism with endometriosis risk in Isfahan.Iranian journal of reproductive medicine · 2013Article
- Study of ultrastructure and apoptosis in the endometrium of women with or without endometriosis.Iranian journal of reproductive medicine · 2013Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEndometriosis is one of the most common gynecologic disorders. It is a complex trait and both genetic and environmental factors have been implicated in its pathogenesis. There is growing evidence indicating that exposure to environmental contaminants is a risk factor for endometriosis. Glutathione-S-Transferase M1 (GSTM1) is one of the genes involved in detoxification of endogenous and exogenous compounds.
objectiveSeveral studies have indicated an association between GSTM1 null mutation and endometriosis. In this study, the possible association between the GSTM1 gene null genotype and susceptibility to endometriosis in woman from central and southern Iran was investigated. MATERIALS AND
methodsOne hundred and one unrelated premenopausal women with endometriosis and 142 unrelated healthy premenopausal women without endometriosis were enrolled in the study. Genomic DNA was extracted from Peripheral blood in all subjects. GSTM1 null genotyping was performed by polymerase chain reaction (PCR).
resultsThere was no significant difference between frequencies of GSTM1 null genotype in case and control groups (50.5% Vs. 52.1%, p=0.804). Furthermore, this genotype was not associated with severity of endometriosis in our sample (p=0.77). Conclusion : further studies involving gene-environment and gene-gene interactions, particularly combination of GSTM1 and other GST gene family polymorphisms are needed.
Indexed as
Identifiers
25242970PMC4163259W1565010086What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.