Evidence map›Paper›PMID 25242865›Full record

ArticleMediators of inflammation2014

Secretoglobin superfamily protein SCGB3A2 deficiency potentiates ovalbumin-induced allergic pulmonary inflammation.

Taketomo Kido, Mitsuhiro Yoneda, Yan Cai, Tsutomu Matsubara, Jerrold M Ward, Shioko Kimura

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mediators of inflammation, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. An update in club cell biology and its potential relevance to chronic obstructive pulmonary disease.American journal of physiology. Lung cellular and molecular physiology · 2023
    Review
  4. Article
  5. Secretoglobin 3A2 protects lung from developing cigarette smoke-induced pulmonary emphysema.The international journal of biochemistry & cell biology · 2023
    Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Spatiotemporal Expression of Three Secretoglobin Proteins, SCGB1A1, SCGB3A1, and SCGB3A2, in Mouse Airway Epithelia.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2019
    Article
  11. Article
  12. Association Between Secretoglobin Family 3A Member 2 (SCGB3A2) Gene Polymorphisms and Asthma in a Korean Population.Medical science monitor : international medical journal of experimental and clinical research · 2017
    Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Taketomo KidoLaboratory of Metabolism, National Cancer Institute, National Institutes of Health, Building 37, Room 3106, NIH, 9000 Rockville Pike, Bethesda, MD 20892, USA ; Institute of Molecular and Cellular Biosciences, The University of Tokyo, Tokyo 113-0032, Japan.
Mitsuhiro YonedaLaboratory of Metabolism, National Cancer Institute, National Institutes of Health, Building 37, Room 3106, NIH, 9000 Rockville Pike, Bethesda, MD 20892, USA.ORCID 0000-0001-6340-1205
Yan CaiLaboratory of Metabolism, National Cancer Institute, National Institutes of Health, Building 37, Room 3106, NIH, 9000 Rockville Pike, Bethesda, MD 20892, USA.
Tsutomu MatsubaraLaboratory of Metabolism, National Cancer Institute, National Institutes of Health, Building 37, Room 3106, NIH, 9000 Rockville Pike, Bethesda, MD 20892, USA ; Department of Anatomy, Graduate School of Medicine, Osaka City University, Osaka 545-8585, Japan.ORCID 0000-0003-1100-1052
Jerrold M WardGlobal VetPathology, Montgomery Village, MD 20866, USA.
Shioko KimuraLaboratory of Metabolism, National Cancer Institute, National Institutes of Health, Building 37, Room 3106, NIH, 9000 Rockville Pike, Bethesda, MD 20892, USA.ORCID 0000-0001-9627-6818
National Institutes of Health · USGlobal VetPathology · US

Funding

Role of Novel Cytokine Secretoglobin (SCGB) 3A2 in LungZIABC010449 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI KIMURA, SHIOKO · 2009 to 2025
$10.3M
Intramural NIH HHS
6 · The paper itself

Abstract

Secretoglobin (SCGB) 3A2, a cytokine-like secretory protein of small molecular weight, which may play a role in lung inflammation, is predominantly expressed in airway epithelial cells. In order to understand the physiological role of SCGB3A2, Scgb3a2(-/-) mice were generated and characterized. Scgb3a2(-/-) mice did not exhibit any overt phenotypes. In ovalbumin- (OVA-) induced airway allergy inflammation model, Scgb3a2(-/-) mice in mixed background showed a decreased OVA-induced airway inflammation, while six times C57BL/6NCr backcrossed congenic Scgb3a2(-/-) mice showed a slight exacerbation of OVA-induced airway inflammation as compared to wild-type littermates. These results indicate that the loss of SCGB3A2 function was influenced by a modifier gene(s) in mixed genetic background and suggest that SCGB3A2 has anti-inflammatory property. The results further suggest the possible use of recombinant human SCGB3A2 as an anti-inflammatory agent.

Indexed as

AnimalsEnzyme-Linked Immunosorbent AssayFemaleInterleukin-13Interleukin-4Interleukin-5MiceOvalbuminPneumoniaPregnancyReverse Transcriptase Polymerase Chain ReactionSecretoglobinsInterleukin-13Interleukin-4Interleukin-5OvalbuminScgb3a2 protein, mouseSecretoglobins

Identifiers

PMID25242865
PMCPMC4163287
OpenAlexW2036916269

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.