Evidence map›Paper›PMID 25242863›Full record

ArticleSensors and actuators. B, Chemical2014

Multichamber Multipotentiostat System for Cellular Microphysiometry.

Eduardo A Lima, Rachel M Snider, Ronald S Reiserer, Jennifer R McKenzie, Danielle W Kimmel, Sven E Eklund, John P Wikswo, David E Cliffel

Abstract read
In one paragraph

Article in Sensors and actuators. B, Chemical, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Microphysiologic systems in female reproductive biology.Experimental biology and medicine (Maywood, N.J.) · 2017
    Review
  4. Circadian hormone control in a human-on-a-chip: In vitro biology's ignored component?Experimental biology and medicine (Maywood, N.J.) · 2017
    Review
  5. Multianalyte Physiological Microanalytical Devices.Annual review of analytical chemistry (Palo Alto, Calif.) · 2017
    Review
  6. Multisensor-integrated organs-on-chips platform for automated and continual in situ monitoring of organoid behaviors.Proceedings of the National Academy of Sciences of the United States of America · 2017
    Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Eduardo A LimaDepartment of Earth, Atmospheric, and Planetary Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts. 02139, USA ; Vanderbilt Institute for Integrative Biosystems Research and Education, Vanderbilt University, Nashville, Tennessee. 37235, USA.
Rachel M SniderDepartment of Chemistry, Vanderbilt University, Nashville, Tennessee. 37235, USA.
Ronald S ReisererVanderbilt Institute for Integrative Biosystems Research and Education, Vanderbilt University, Nashville, Tennessee. 37235, USA ; Department of Physics and Astronomy, Vanderbilt University, Nashville, Tennessee. 37235, USA.
Jennifer R McKenzieVanderbilt Institute for Integrative Biosystems Research and Education, Vanderbilt University, Nashville, Tennessee. 37235, USA ; Department of Chemistry, Vanderbilt University, Nashville, Tennessee. 37235, USA.
Danielle W KimmelDepartment of Chemistry, Vanderbilt University, Nashville, Tennessee. 37235, USA.
Sven E EklundDepartment of Chemistry, Vanderbilt University, Nashville, Tennessee. 37235, USA.
John P WikswoVanderbilt Institute for Integrative Biosystems Research and Education, Vanderbilt University, Nashville, Tennessee. 37235, USA ; Department of Physics and Astronomy, Vanderbilt University, Nashville, Tennessee. 37235, USA ; Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee. 37235, USA ; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee. 37235, USA.
David E CliffelVanderbilt Institute for Integrative Biosystems Research and Education, Vanderbilt University, Nashville, Tennessee. 37235, USA ; Department of Chemistry, Vanderbilt University, Nashville, Tennessee. 37235, USA.

Funding

Chemistry-Biology Interface Training GrantT32GM065086 · NIGMS · VANDERBILT UNIVERSITY · PI BACHMANN, BRIAN O, SULIKOWSKI, GARY ALLEN · 2002 to 2022
$7.0M
Metabolic Discrimination of Unknown Bacterial PathogensU01AI061223 · NIAID · VANDERBILT UNIVERSITY · PI WIKSWO, JOHN PETER · 2005 to 2009
$5.2M
NIAID NIH HHS U01 AI061223NIGMS NIH HHS T32 GM065086
6 · The paper itself

Abstract

Multianalyte microphysiometry is a powerful technique for studying cellular metabolic flux in real time. Monitoring several analytes concurrently in a number of individual chambers, however, requires specific instrumentation that is not available commercially in a single, compact, benchtop form at an affordable cost. We developed a multipotentiostat system capable of performing simultaneous amperometric and potentiometric measurements in up to eight individual chambers. The modular design and custom LabVIEW™ control software provide flexibility and allow for expansion and modification to suit different experimental conditions. Superior accuracy is achieved when operating the instrument in a standalone configuration; however, measurements performed in conjunction with a previously developed multianalyte microphysiometer have shown low levels of crosstalk as well. Calibrations and experiments with primary and immortalized cell cultures demonstrate the performance of the instrument and its capabilities.

Indexed as

Keywords1: multipotentiostatmicrophysiologymicrophysiometry

Identifiers

PMID25242863
PMCPMC4167374

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.