ArticleMuscle & nerve2015
Characterization of a compartment syndrome-like injury model.
Article in Muscle & nerve, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 26 citations in OpenAlex.
- Researcher's guide to preclinical animal models of acute extremity compartment syndrome.Trauma surgery & acute care open · 2025Review
- Porcine blast injury model achieves prolonged elevation of intra-compartmental pressures without exogenous pressure manipulation.Journal of orthopaedic surgery and research · 2024Article
- Establishment and pathophysiological evaluation of a novel model of acute compartment syndrome in rats.BMC musculoskeletal disorders · 2024Article
- Extracellular vesicles derived from human ESC-MSCs target macrophage and promote anti-inflammation process, angiogenesis, and functional recovery in ACS-induced severe skeletal muscle injury.Stem cell research & therapy · 2023Article
- Electrical impedance myography for the early detection of muscle ischemia secondary to compartment syndrome: a study in a rat model.Scientific reports · 2023Article
- Early assessment of extremity compartment syndrome by biochemical markers in a rat model.Turkish journal of medical sciences · 2023Article
- Embryonic stem cell-derived mesenchymal stem cells alleviate skeletal muscle injury induced by acute compartment syndrome.Stem cell research & therapy · 2022Article
- Development of a Rat Model of Fasciotomy Treatment for Compartment Syndrome.Tissue engineering. Part C, Methods · 2022Article
- Administration of particulate oxygen generators improves skeletal muscle contractile function after ischemia-reperfusion injury in the rat hindlimb.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Article
- The association between intracompartmental pressure and skeletal muscle recovery after tibial diaphyseal fractures: an ambispective cohort study.Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology · 2021Observational
- Review
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Authors and funding
6 authors at 1 institution in 1 country.
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Abstract
introductionAcute compartment syndrome (CS) is caused by an elevation of pressure within a muscular compartment that can be caused by numerous factors, including blunt trauma. In this study, we characterized a rodent model of CS-like injury.
methodsForty male athymic rats received a standardized injury of ischemia and compression to their hindlimbs, while the intracompartmental pressure (ICP) was measured using an implantable transmitter. Tetanic muscle function was evaluated, and histology was performed on the tibialis anterior (TA) muscle.
resultsICPs were held at 260.70 ± 2.70 mm Hg during injury. Injured muscles recovered 59% of their total function 4 weeks after injury, and histology showed high levels of edema, inflammation (CD68(+) ), angiogenesis (CD31(+) ), and fibrosis within 72 hours after injury.
conclusionsWe describe a novel CS-like injury model and a novel method to measure ICP, which could potentially be used to develop innovative therapies to manage CS injury in patients.
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