ArticleNeuroscience2014
Chronic stress may facilitate the recruitment of habit- and addiction-related neurocircuitries through neuronal restructuring of the striatum.
Article in Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
39 citing papers in PubMed, 76 citations in OpenAlex.
- A basolateral amygdala to dorsolateral striatum projection modulates stimulus-evoked motor behavior.Neuron · 2026Article
- Corticosteroid Receptor Modulation in the Dorsal Striatum Prevents Morphine-Induced Place Preference and Reduction in Dopamine Transporter (DAT) Immunoreactivity in Rats.Addiction biology · 2026Article
- Structural remodeling of medium spiny neurons in the tail of the striatum and stress-related behavioral alterations after early handling and adolescent stress in male rats.IBRO neuroscience reports · 2026Article
- Investigating Substance Use as a Coping Strategy Among Adolescent Psychiatric Inpatients: A Comparative Analysis Before and During the COVID-19 Pandemic.Child psychiatry and human development · 2026Article
- Corticosterone accelerates behavioral inflexibility via plasticity-related gene expression in the dorsal striatum.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- From Stress to Substance Use Disorders: The Expanding Role of Microglia-Astrocyte Crosstalk in Neuroimmune and Glutamate Alterations in the Nucleus Accumbens.International journal of molecular sciences · 2025Review
- Cumulative lifetime stressor exposure impairs stimulus-response but not contextual learning.Scientific reports · 2024Article
- Acute stress facilitates habitual behavior in female rats.Physiology & behavior · 2024Article
- Stress, associative learning, and decision-making.Neurobiology of learning and memory · 2023Review
- Neurocognitive effects of stress: a metaparadigm perspective.Molecular psychiatry · 2023Review
- Striatopallidal adenosine ANeuropharmacology · 2023Review
- Elevated prefrontal dopamine interferes with the stress-buffering properties of behavioral control in female rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Chronic alcohol consumption shifts learning strategies and synaptic plasticity from hippocampus to striatum-dependent pathways.Frontiers in psychiatry · 2023Article
- Convergent actions of stress and stimulants via epigenetic regulation of neural circuitry.Trends in neurosciences · 2022Review
- Habit Formation and the Effect of Repeated Stress Exposures on Cognitive Flexibility Learning in Horses.Animals : an open access journal from MDPI · 2022Article
- Impact of putamen inhibition by DREADDs on schedule-induced drinking in rhesus monkeys.Journal of the experimental analysis of behavior · 2022Article
- Adolescent social isolation induced alterations in nucleus accumbens glutamate signalling.Addiction biology · 2022Article
- Interactive relations between maternal prenatal stress, fetal brain connectivity, and gestational age at delivery.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Long-Term Impacts of Post-weaning Social Isolation on Nucleus Accumbens Function.Frontiers in psychiatry · 2021Review
- Threat-induced modulation of hippocampal and striatal memory systems during navigation of a virtual environment.Neurobiology of learning and memory · 2020Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Chronic stress is an established risk factor in the development of addiction. Addiction is characterized by a progressive transition from casual drug use to habitual and compulsive drug use. The ability of chronic stress to facilitate the transition to addiction may be mediated by increased engagement of the neurocircuitries underlying habitual behavior and addiction. In the present study, striatal morphology was evaluated after 2 weeks of chronic variable stress in male Sprague-Dawley rats. Dendritic complexity of medium spiny neurons was visualized and quantified with Golgi staining in the dorsolateral and dorsomedial striatum, as well as in the nucleus accumbens core and shell. In separate cohorts, the effects of chronic stress on habitual behavior and the acute locomotor response to methamphetamine were also assessed. Chronic stress resulted in increased dendritic complexity in the dorsolateral striatum and nucleus accumbens core, regions implicated in habitual behavior and addiction, while decreased complexity was found in the nucleus accumbens shell, a region critical for the initial rewarding effects of drugs of abuse. Chronic stress did not affect dendritic complexity in the dorsomedial striatum. A parallel shift toward habitual learning strategies following chronic stress was also identified. There was an initial reduction in acute locomotor response to methamphetamine, but no lasting effect as a result of chronic stress exposure. These findings suggest that chronic stress may facilitate the recruitment of habit- and addiction-related neurocircuitries through neuronal restructuring in the striatum.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.