ReviewNature chemistry2014
Contemporary screening approaches to reaction discovery and development.
Review in Nature chemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
67 citing papers in PubMed.
- Chiral Analysis for High-Throughput Reaction Screening: Recent Advances in Accelerating Asymmetric Catalysis Discovery.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Review
- A General Group Testing Strategy for Discovering Chemical Cooperativity.Angewandte Chemie (International ed. in English) · 2026Article
- Advancing Organic Chemistry Using High-Throughput Experimentation.Angewandte Chemie (International ed. in English) · 2025Review
- Evolving Data-Driven Strategies for the Characterization of Supramolecular Polymers and Systems.Angewandte Chemie (International ed. in English) · 2025Review
- Rapid Exploration of Chemical Space by High-Throughput Desorption Electrospray Ionization Mass Spectrometry.Journal of the American Chemical Society · 2024Article
- Self-Driving Laboratories for Chemistry and Materials Science.Chemical reviews · 2024Review
- Bridging the information gap in organic chemical reactions.Nature chemistry · 2024Review
- Development of a selective and scalableRSC advances · 2024Article
- Enabling High Throughput Kinetic Experimentation by Using Flow as a Differential Kinetic Technique.Angewandte Chemie (International ed. in English) · 2024Article
- Predicting success in Cu-catalyzed C-N coupling reactions using data science.Science advances · 2024Article
- Quantum chemical calculations for reaction prediction in the development of synthetic methodologies.Chemical science · 2023Review
- Ultra-high-throughput mapping of the chemical space of asymmetric catalysis enables accelerated reaction discovery.Nature communications · 2023Article
- The rise of automated curiosity-driven discoveries in chemistry.Chemical science · 2023Review
- High-Throughput Diversification of Complex Bioactive Molecules by Accelerated Synthesis in Microdroplets.Angewandte Chemie (International ed. in English) · 2023Article
- Ni-catalyzed mild hydrogenolysis and oxidations of C-O bonds via carbonate redox tags.Nature communications · 2023Article
- Digitizing chemical discovery with a Bayesian explorer for interpreting reactivity data.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Machine-Learning-Guided Discovery of Electrochemical Reactions.Journal of the American Chemical Society · 2022Article
- Iminologous epoxide ring-closure.Chemical science · 2022Article
- High-Throughput Platform for Novel Reaction Discovery.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022Article
- Biomacromolecule-Assisted Screening for Reaction Discovery and Catalyst Optimization.Chemical reviews · 2022Review
7 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
New organic reactivity has often been discovered by happenstance. Several recent research efforts have attempted to leverage this to discover new reactions. In this Review, we attempt to unify reported approaches to reaction discovery on the basis of the practical and strategic principles applied. We concentrate on approaches to reaction discovery as opposed to reaction development, though conceptually groundbreaking approaches to identifying efficient catalyst systems are also considered. Finally, we provide a critical overview of the utility and application of the reported methods from the perspective of a synthetic chemist, and consider the future of high-throughput screening in reaction discovery.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.