ArticleScientific reports2014
Human germ cell formation in xenotransplants of induced pluripotent stem cells carrying X chromosome aneuploidies.
Article in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Turner syndrome: the promise of fertility via stem cell technology.Hormones (Athens, Greece) · 2025Review
- Interactions among insulin resistance, epigenetics, and donor sex in gene expression regulation of iPSC-derived myoblasts.The Journal of clinical investigation · 2024Article
- Competing endogenous RNA network analysis of Turner syndrome patient-specific iPSC-derived cardiomyocytes reveals dysregulation of autosomal heart development genes by altered dosages of X-inactivation escaping non-coding RNAs.Stem cell research & therapy · 2023Article
- Transcriptional control of human gametogenesis.Human reproduction update · 2022Article
- Generation of Primordial Germ Cell-like Cells from iPSCs Derived from Turner Syndrome Patients.Cells · 2021Article
- Studying Abnormal Chromosomal Diseases Using Patient-Derived Induced Pluripotent Stem Cells.Frontiers in cellular neuroscience · 2020Article
- Generation of Artificial Gamete and Embryo From Stem Cells in Reproductive Medicine.Frontiers in bioengineering and biotechnology · 2020Review
- A PAX5-OCT4-PRDM1 developmental switch specifies human primordial germ cells.Nature cell biology · 2018Article
- Human somatic cells subjected to genetic induction with six germ line-related factors display meiotic germ cell-like features.Scientific reports · 2016Article
- Experimental methods to preserve male fertility and treat male factor infertility.Fertility and sterility · 2016Review
- Article
- Dynamic and social behaviors of human pluripotent stem cells.Scientific reports · 2015Article
- Single-Cell XIST Expression in Human Preimplantation Embryos and Newly Reprogrammed Female Induced Pluripotent Stem Cells.Stem cells (Dayton, Ohio) · 2015Article
- Artificial gametes from stem cells.Clinical and experimental reproductive medicine · 2015Review
- Uniparental disomy of the entire X chromosome in Turner syndrome patient-specific induced pluripotent stem cells.Cell discovery · 2015Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Turner syndrome is caused by complete or partial loss of the second sex chromosome and is characterized by spontaneous fetal loss in >90% of conceptions. Survivors possess an array of somatic and germline clinical characteristics. Induced pluripotent stem cells (iPSCs) offer an opportunity for insight into genetic requirements of the X chromosome linked to Turner syndrome. We derived iPSCs from Turner syndrome and control individuals and examined germ cell development as a function of X chromosome composition. We demonstrate that two X chromosomes are not necessary for reprogramming or maintenance of pluripotency and that there are minimal differences in gene expression, at the single cell level, linked to X chromosome aneuploidies. Formation of germ cells, as assessed in vivo through a murine xenotransplantation model, indicated that undifferentiated iPSCs, independent of X chromosome composition, are capable of forming germ-cell-like cells (GCLCs) in vivo. In combination with clinical data regarding infertility in women with X chromosome aneuploidies, results suggest that two intact X chromosomes are not required for human germ cell formation, qualitatively or quantitatively, but rather are likely to be required for maintenance of human germ cells to adulthood.
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