ReviewHead & neck2016
Update on primary head and neck mucosal melanoma.
Review in Head & neck, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
77 citing papers in PubMed, 1 synthesis or guideline pooled it, 205 citations in OpenAlex.
- Metastatic melanoma of the major salivary glands - a systematic review.Medicina oral, patologia oral y cirugia bucal · 2025Pooled it
- Head and Neck Mucosal Melanoma in the Era of Immunotherapy: A National Cancer Database Review.Head & neck · 2026Article
- Oral malignant melanoma of the tongue with suspected intralingual in-transit metastasis.BMJ case reports · 2026Article
- Hypomelanotic melanoma of the mandibular gingiva: a case report and literature review.BMC oral health · 2026Review
- Hypofractionated Spot Scanning Proton Therapy for Head and Neck Mucosal Melanoma: A Retrospective Analysis With Quality-of-Life Outcome.Head & neck · 2026Article
- Establishment and characterization of a cell line (OS-MM) originating from a human malignant melanoma of the oral mucosa.In vitro cellular & developmental biology. Animal · 2026Article
- Mucosal Melanoma of the Head and Neck: A 45-Year Experience of a Tertiary Cancer Center.Cancers · 2026Article
- Unveiling the Importance of Early Detection of Oral Mucosal Melanoma with Non-Invasive Imaging Techniques.Diagnostics (Basel, Switzerland) · 2026Review
- Mucosal melanoma of the head and neck region: clinical-pathologic implications of tumor microenvironment evaluated with multiplex immunohistochemistry.Virchows Archiv : an international journal of pathology · 2026Article
- Oral Mucosal Melanoma In Situ Manifesting as Multiple Gingival Macules Around a Dental Implant-Based Prosthesis: A Case Report.Case reports in dentistry · 2026Article
- A Rare Case of Aggressive Tongue Malignant Melanoma: Clinical Presentation and Treatment Approach.Cureus · 2025Article
- Sinonasal Mucosal Melanoma: A Comprehensive Review and Clinical Experience.Journal of rhinology : official journal of the Korean Rhinologic Society · 2025Review
- Pigmented Lesions of the Oral Mucosa: Clinical Presentation, Histology, and Recommendations for Management.American journal of clinical dermatology · 2025Review
- Article
- Amelanotic Melanocytic Nevus of the Oral Cavity: A Case Report and Literature Review.Diagnostics (Basel, Switzerland) · 2025Article
- Recurrent Malignant Melanoma on the Tongue: A Case Report and Review of the Literature.Cancer reports (Hoboken, N.J.) · 2025Review
- Chinese expert consensus on imaging examination and diagnosis of nasal cavity and paranasal sinus tumors.Frontiers in oncology · 2025Review
- Local Control of Conjunctival Malignant Melanoma by Proton Beam Therapy in a Patient With No Metastasis in Six Years FromJournal of medical cases · 2025Article
- Minimal invasive treatment of liver and kidney metastasis in mucosal melanoma of the right inferior turbinate.Radiology case reports · 2024Article
- Isolated hyperthermic perfusions for cutaneous melanoma in-transit metastasis of the limb and uveal melanoma metastasis to the liver.Clinical & experimental metastasis · 2024Review
17 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 15 institutions in 6 countries.
Funding
Abstract
Primary mucosal melanomas (PMMs) of the head and neck are uncommon malignancies that arise mainly in the nasal cavity and paranasal sinuses, followed by the oral cavity. The mainstay of treatment is radical surgical resection followed by adjuvant radiotherapy in selected patients with high-risk features. Multimodality therapy has not been well studied and is not standardized. Adjuvant radiotherapy seems to improve locoregional control but does not improve overall survival (OS). Elective neck dissection is advocated in patients with oral PMM. Systemic therapy should be considered only for patients with metastatic or unresectable locoregional disease. Despite improvements in the field of surgery, radiotherapy, and systemic therapy, patients with PMM still face a very unfavorable prognosis (5-year disease-free survival [DFS] <20%) with high rates of locoregional recurrence and distant metastasis. The present review aims to summarize the current state of knowledge on the molecular biology, pathological diagnosis, and management of this disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.