ArticleNature neuroscience2014
Tactile frequency discrimination is enhanced by circumventing neocortical adaptation.
Article in Nature neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed.
- Cortical circuit implementation of signed deviant detection with positive and negative prediction error neurons.bioRxiv : the preprint server for biology · 2026Article
- Vibrotactile Stimulation Encoded by Beta and Gamma Bands Varies with Locations on the Upper Limbs.Bioengineering (Basel, Switzerland) · 2026Article
- Neural correlates of perceptual decision-making in the primary somatosensory cortex.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Cortical spectral dynamics of vibrotactile frequency processing.Scientific reports · 2025Article
- A tactile discrimination task to study neuronal dynamics in freely-moving mice.Nature communications · 2025Article
- Corticothalamic modulation of somatosensory thalamic tactile processing.The Journal of physiology · 2025Article
- Sensory adaptation in the barrel cortex during active sensation in the behaving mouse.Scientific reports · 2024Article
- A latent pool of neurons silenced by sensory-evoked inhibition can be recruited to enhance perception.Neuron · 2024Article
- Coexistence of state, choice, and sensory integration coding in barrel cortex LII/III.Nature communications · 2024Article
- Cortical astrocyte N-methyl-D-aspartate receptors influence whisker barrel activity and sensory discrimination in mice.Nature communications · 2024Article
- Rapid adaptation of primate LGN neurons to drifting grating stimulation.Journal of neurophysiology · 2023Article
- Modelling novelty detection in the thalamocortical loop.PLoS computational biology · 2023Article
- Two-photon calcium imaging of neuronal activity.Nature reviews. Methods primers · 2022Article
- Rapid Cortical Adaptation and the Role of Thalamic Synchrony during Wakefulness.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Sensory Adaptation in the Whisker-Mediated Tactile System: Physiology, Theory, and Function.Frontiers in neuroscience · 2021Review
- Non-invasive molecularly-specific millimeter-resolution manipulation of brain circuits by ultrasound-mediated aggregation and uncaging of drug carriers.Nature communications · 2020Article
- The effect of NMDA-R antagonist, MK-801, on neuronal mismatch along the rat auditory thalamocortical pathway.Scientific reports · 2020Article
- Article
- Multiple Timescales Account for Adaptive Responses across Sensory Cortices.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Sensorimotor processing in the rodent barrel cortex.Nature reviews. Neuroscience · 2019Review
Corrections and comments
- Commented on by
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neocortical responses typically adapt to repeated sensory stimulation, improving sensitivity to stimulus changes, but possibly also imposing limitations on perception. For example, it is unclear whether information about stimulus frequency is perturbed by adaptation or encoded by precise response timing. We addressed this question in rat barrel cortex by comparing performance in behavioral tasks with either whisker stimulation, which causes frequency-dependent adaptation, or optical activation of cortically expressed channelrhodopsin-2, which elicits non-adapting neural responses. Circumventing adaption by optical activation substantially improved cross-hemispheric discrimination of stimulus frequency. This improvement persisted when temporal precision of optically evoked spikes was reduced. We were able to replicate whisker-driven behavior only by applying adaptation rules mimicking sensory-evoked responses to optical stimuli. Conversely, in a change-detection task, animals performed better with whisker than optical stimulation. Our results directly demonstrate that sensory adaptation critically governs the perception of stimulus patterns, decreasing fidelity under steady-state conditions in favor of change detection.
Indexed as
Identifiers
25242306What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.