Evidence map›Paper›PMID 25242219›Full record

ArticleNeuron2014

Orbitofrontal cortex is required for optimal waiting based on decision confidence.

Armin Lak, Gil M Costa, Erin Romberg, Alexei A Koulakov, Zachary F Mainen, Adam Kepecs

Open access · bronzeAbstract read
In one paragraph

Article in Neuron, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 129 papers.

0numbers the graph read from it
0cells of the map it votes in
129citing papers in PubMed
8.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

129 citing papers in PubMed, 226 citations in OpenAlex.

  1. Trial
  2. Towards an integrative neuroscience of metacognition.Nature reviews. Neuroscience · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Addressing degeneracy in rodent studies of cognition.Current opinion in neurobiology · 2026
    Review
  9. Review
  10. Article
  11. Article
  12. Neuronal Activity in Orbitofrontal Cortex during Trinary Choices under Risk.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  13. Article
  14. Article
  15. The virtue of temperance: a neurobiological perspective.Frontiers in human neuroscience · 2026
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

69 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Armin LakCold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA.
Gil M CostaCold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA; Champalimaud Neuroscience Programme, Champalimaud Centre for the Unknown, Avenue Brasília s/n, 1400-038 Lisbon, Portugal.
Erin RombergCold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA.
Alexei A KoulakovCold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA.
Zachary F MainenChampalimaud Neuroscience Programme, Champalimaud Centre for the Unknown, Avenue Brasília s/n, 1400-038 Lisbon, Portugal.
Adam KepecsCold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA. Electronic address: kepecs@cshl.edu.
Cold Spring Harbor Laboratory · USChampalimaud Foundation · PT

Funding

Decision confidence: neural coding and causal circuit mechanisms in behaviorR01MH097061 · NIMH · WASHINGTON UNIVERSITY · PI KEPECS, ADAM · 2014 to 2024
$4.7M
CRCNS: Theory and experiment of neural circuit mapping by DNA sequencingR01DA036913 · NIDA · COLD SPRING HARBOR LABORATORY · PI KOULAKOV, ALEXEI, ZADOR, ANTHONY M · 2013 to 2017
$2.1M
NIDA NIH HHS R01 DA036913NIMH NIH HHS R01 MH097061NIMH NIH HHS R01MH097061
6 · The paper itself

Abstract

Confidence judgments are a central example of metacognition-knowledge about one's own cognitive processes. According to this metacognitive view, confidence reports are generated by a second-order monitoring process based on the quality of internal representations about beliefs. Although neural correlates of decision confidence have been recently identified in humans and other animals, it is not well understood whether there are brain areas specifically important for confidence monitoring. To address this issue, we designed a postdecision temporal wagering task in which rats expressed choice confidence by the amount of time they were willing to wait for reward. We found that orbitofrontal cortex inactivation disrupts waiting-based confidence reports without affecting decision accuracy. Furthermore, we show that a normative model can quantitatively account for waiting times based on the computation of decision confidence. These results establish an anatomical locus for a metacognitive report, confidence judgment, distinct from the processes required for perceptual decisions.

Indexed as

AnimalsChoice BehaviorDecision MakingMalePrefrontal CortexRatsRats, Long-EvansReaction Time

Identifiers

PMID25242219
PMCPMC4364549
OpenAlexW2119707473

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.