Evidence map›Paper›PMID 25242135›Full record

ArticleOral oncology2014

Novel DNA methylation targets in oral rinse samples predict survival of patients with oral squamous cell carcinoma.

Scott M Langevin, Rondi A Butler, Melissa Eliot, Michael Pawlita, Jennifer Z J Maccani, Michael D McClean, Karl T Kelsey

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oral oncology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Scott M LangevinDepartment of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, OH, USA. Electronic address: langevst@uc.edu.
Rondi A ButlerDepartment of Epidemiology, Brown University, Providence, RI, USA.
Melissa EliotDepartment of Epidemiology, Brown University, Providence, RI, USA.
Michael PawlitaResearch Program Infection and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Jennifer Z J MaccaniDepartment of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, RI, USA; Centers for Behavioral and Preventive Medicine, The Miriam Hospital, Providence, RI, USA.
Michael D McCleanDepartment of Environmental Health, Boston University School of Public Health, Boston, MA, USA.
Karl T KelseyDepartment of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Department of Pathology and Laboratory Medicine, Brown University, Providence, RI, USA.

Funding

Patterns of Somatic Gene Alterations in Oral CancerR01CA100679 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI KELSEY, KARL TIMOTHY · 2004 to 2012
$2.6M
Epigenetic alterations in oral rinse as biomarkers of oral and pharyngeal cancerK22CA172358 · NCI · UNIVERSITY OF CINCINNATI · PI LANGEVIN, SCOTT M. · 2013 to 2015
$312k
NCI NIH HHS K22 CA172358NCI NIH HHS K22CA172358NCI NIH HHS R01 CA100679NCI NIH HHS R01CA100679
6 · The paper itself

Abstract

objectivesThe objective of this study was to identify novel survival-associated biomarkers in oral rinse samples collected from patients with oral squamous cell carcinoma (OSCC). MATERIALS AND

methodsWe screened for putative survival-associated markers using publicly available methylation array data from 88 OSCC tumors. Cox models were then fit to methylation array data restricted to these putative loci in oral rinse samples of 82 OSCC patients from greater Boston. Pyrosequencing assays were designed for each locus that replicated in the oral rinse samples and applied to a validation set of oral rinse samples from another 61 OSCC patients.

resultsWe identified 7 survival-associated methylation markers in oral rinse samples from OSCC patients, and have validated one, located in the body of GABBR1, by pyrosequencing.

conclusionThe 7 CpG loci identified through this study represent novel prognostic biomarkers for patients with OSCC that can be detected using a non-invasive oral rinse collection technique.

Indexed as

DNA MethylationAdultAgedAged, 80 and overCarcinoma, Squamous CellFemaleHumansMaleMiddle AgedMouth NeoplasmsSurvival AnalysisYoung AdultEpigenomicsGABBR1MouthwashOral cancerPrognosis

Identifiers

PMID25242135
PMCPMC4254027

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.