Evidence map›Paper›PMID 25242116›Full record

ReviewTrends in cell biology2015

Refining the role for adult stem cells as cancer cells of origin.

Andrew C White, William E Lowry

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Trends in cell biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
83citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

83 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Fraternal cooperation of hierarchical cancer parallels metazoan multicellularity and eusociality.Biological reviews of the Cambridge Philosophical Society · 2026
    Review
  8. Article
  9. Review
  10. Article
  11. Shaping the future of urogynecology through regenerative medicine.Current opinion in obstetrics & gynecology · 2025
    Review
  12. Review
  13. Article
  14. Purinergic system in cancer stem cells.Purinergic signalling · 2025
    Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Review

23 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Andrew C WhiteEli and Edythe Broad Center for Regenerative Medicine, UCLA, Los Angeles, LA, USA; Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, LA, USA; Molecular Biology Institute, UCLA, Los Angeles, LA, USA; Department of Molecular, Cell and Developmental Biology, UCLA, Los Angeles, LA, USA.
William E LowryEli and Edythe Broad Center for Regenerative Medicine, UCLA, Los Angeles, LA, USA; Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, LA, USA; Molecular Biology Institute, UCLA, Los Angeles, LA, USA; Department of Molecular, Cell and Developmental Biology, UCLA, Los Angeles, LA, USA. Electronic address: blowry@ucla.edu.

Funding

Identification and characterization of cancer cells of origin in the epidermisR01AR057409 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LOWRY, WILLIAM E · 2010 to 2014
$1.7M
NIAMS NIH HHS R01 AR057409
6 · The paper itself

Abstract

Significant progress has been made to identify the cells at the foundation of tumorigenesis, the cancer cell of origin (CCO). The majority of data points towards resident adult stem cells (ASCs) or primitive progenitors as the CCO for those cancers studied, highlighting the importance of stem cells not only as propagators but also as initiators of cancer. Recent data suggest tumor initiation at the CCOs can be regulated through both intrinsic and extrinsic signals and that the identity of the CCOs and their propensity to initiate tumorigenesis is context dependent. In this review, we summarize some of the recent findings regarding CCOs and solid tumor initiation and highlight its relation with bona fide human cancer.

Indexed as

Adult Stem CellsCarcinogenesisCell Transformation, NeoplasticHumansNeoplasmsSignal TransductionStem Cellscancer cells of origingenetic hitsstem cell nichetumor initiation

Identifiers

PMID25242116
PMCPMC4275355

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.