ArticleReproductive toxicology (Elmsford, N.Y.)2014
Soy but not bisphenol A (BPA) induces hallmarks of polycystic ovary syndrome (PCOS) and related metabolic co-morbidities in rats.
Article in Reproductive toxicology (Elmsford, N.Y.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed.
- Article
- Bisphenol A in Water Systems: Risks to Polycystic Ovary Syndrome and Biochar-Based Adsorption Remediation: A Review.Chemistry & biodiversity · 2024Review
- An Overview of the Health Effects of Bisphenol A from a One Health Perspective.Animals : an open access journal from MDPI · 2023Review
- The Implication of Mechanistic Approaches and the Role of the Microbiome in Polycystic Ovary Syndrome (PCOS): A Review.Metabolites · 2023Review
- Advancements in lead therapeutic phytochemicals polycystic ovary syndrome: A review.Frontiers in pharmacology · 2022Review
- Effects of Soy Isoflavones, Resistant Starch and Antibiotics on Polycystic Ovary Syndrome (PCOS)-Like Features in Letrozole-Treated Rats.Nutrients · 2021Article
- IsPathogens (Basel, Switzerland) · 2021Article
- Endocrine disruptors, obesity, and cytokines - how relevant are they to PCOS?Physiological research · 2020Article
- Bisphenol A: an emerging threat to female fertility.Reproductive biology and endocrinology : RB&E · 2020Review
- Animal Models for Human Polycystic Ovary Syndrome (PCOS) Focused on the Use of Indirect Hormonal Perturbations: A Review of the Literature.International journal of molecular sciences · 2019Review
- Effects of bisphenol A and its analogs on reproductive health: A mini review.Reproductive toxicology (Elmsford, N.Y.) · 2018Review
- Deficiency of Gpr1 improves steroid hormone abnormality in hyperandrogenized mice.Reproductive biology and endocrinology : RB&E · 2018Article
- Endocrine disruption by dietary phyto-oestrogens: impact on dimorphic sexual systems and behaviours.The Proceedings of the Nutrition Society · 2017Review
- Soy Formula and Epigenetic Modifications: Analysis of Vaginal Epithelial Cells from Infant Girls in the IFED Study.Environmental health perspectives · 2017Article
- Comparison of endpoints relevant to toxicity assessments in 3 generations of CD-1 mice fed irradiated natural and purified ingredient diets with varying soy protein and isoflavone contents.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2016Article
- EDC-2: The Endocrine Society's Second Scientific Statement on Endocrine-Disrupting Chemicals.Endocrine reviews · 2015Review
- Soy but not bisphenol A (BPA) or the phytoestrogen genistin alters developmental weight gain and food intake in pregnant rats and their offspring.Reproductive toxicology (Elmsford, N.Y.) · 2015Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Polycystic ovarian syndrome (PCOS) is the most common female endocrine disorder with a prevalence as high as 8-15% depending on ethnicity and the diagnostic criteria employed. The basic pathophysiology and mode of inheritance remain unclear, but environmental factors such as diet, stress and chemical exposures are thought to be contributory. Developmental exposure to endocrine disrupting compounds (EDCs) have been hypothesized to exacerbate risk, in part because PCOS hallmarks and associated metabolic co-morbidities can be reliably induced in animal models by perinatal androgen exposure. Here we show that lifetime exposure to a soy diet, containing endocrine active phytoestrogens, but not developmental exposure (gestational day 6-lactational day 40) to the endocrine disrupting monomer bisphenol A (BPA), can induce key features of PCOS in the rat; results which support the hypothesis that hormonally active diets may contribute to risk when consumed throughout gestation and post-natal life.
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Registered trials
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