ArticleRedox report : communications in free radical research2015
Effect of exercise training on oxidative stress and mitochondrial function in rat heart and gastrocnemius muscle.
Article in Redox report : communications in free radical research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Effect of exercise training on cardiac mitochondrial respiration, biogenesis, dynamics, and mitophagy in ischemic heart disease.Frontiers in cardiovascular medicine · 2022Pooled it
- Plasticity and evolved changes in mitochondrial physiology across skeletal muscles of high-altitude deer mice (Peromyscus maniculatus).The Journal of experimental biology · 2026Article
- Exploring the effects of lifelong aerobic exercise on early skeletal muscle remodeling between 8 and 14 months in the rat.Journal of physiology and biochemistry · 2026Article
- Mitochondria: the central hub linking exercise to enhanced cardiac function.Frontiers in physiology · 2026Review
- Effects of selenium, selenium-enriched spirulina and phycocyanin on myocarditis stress parameters on LPS-induced injury in H9c2 ventricular cardiomyoblasts.Physiological reports · 2025Article
- Migration increases mitochondrial oxidative capacity without increasing reactive oxygen species emission in a songbird.The Journal of experimental biology · 2024Article
- Moderate intensity continuous versus high intensity interval training: Metabolic responses of slow and fast skeletal muscles in rat.PloS one · 2023Article
- Exercise training attenuates pulmonary inflammation and mitochondrial dysfunction in a mouse model of high-fat high-carbohydrate-induced NAFLD.BMC medicine · 2022Article
- Exercise Improves Redox Homeostasis and Mitochondrial Function in White Adipose Tissue.Antioxidants (Basel, Switzerland) · 2022Article
- Influence of biological sex and exercise on murine cardiac metabolism.Journal of sport and health science · 2022Article
- The Effect of Acute Aerobic Exercise on Redox Homeostasis and Mitochondrial Function of Rat White Adipose Tissue.Oxidative medicine and cellular longevity · 2021Article
- Review
- Effect of personalized moderate exercise training on Wistar rats fed with a fructose enriched water.Nutrition & metabolism · 2018Article
- Reactive Oxygen Species as Intracellular Signaling Molecules in the Cardiovascular System.Current cardiology reviews · 2018Review
- Gender-dependent differences of mitochondrial function and oxidative stress in rat skeletal muscle at rest and after exercise training.Redox report : communications in free radical research · 2017Article
- Low Intensity Physical Exercise Attenuates Cardiac Remodeling and Myocardial Oxidative Stress and Dysfunction in Diabetic Rats.Journal of diabetes research · 2015Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study aimed to explore the effect of endurance training on oxidative parameters and mitochondrial function in gastrocnemius and heart muscle.
methodsMale Wistar rats were trained by running for 6 weeks. In vitro measurements of the rates of hydroxyl radical ((•)OH) production, oxygen consumption (in either the absence, basal rate (V0), or the presence, maximal rate (Vmax), of adenosine diphosphate), and adenosine triphosphate (ATP) production were made simultaneously in permeabilized fibers. The mitochondrial function was explored after exposure or non-exposure to an in vitro generator system of reactive oxygen species (ROS).
resultsVmax was not affected by training, but V0 decreased. In conditions of maximal mitochondrial functioning, an increase in ATP rate and a decrease in (•)OH production occurred simultaneously. In vitro ROS exposure disturbed mitochondrial function, but training modified the vulnerability of Vmax and ATP rate to ROS in different ways. DISCUSSION: We hypothesize that the part of Vmax devoted to proton leakage was decreased in trained rats, consequently improving ATP synthesis. The data suggest that, after training, there is more efficient use of electrons in respiratory chain energy production, rather than a greater ROS scavenging capacity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.